Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172854955> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2172854955 endingPage "1247" @default.
- W2172854955 startingPage "1240" @default.
- W2172854955 abstract "Self-emulsifying drug delivery system (SEDDS) is the isotropic and thermodynamically stable mixture of oil, surfactant, co-solvent/surfactant, and drug. It emulsifies spontaneously when introduced into an aqueous phase under a mild agitation. The current study was aimed to prepare SNEDDS to augment solubility, release rate, and oral bioavailability of BCS class II drug, efavirenz (EFV). A series of oil, surfactant, and co-surfactant was screened out by a ternary phase diagram to locate a better homogenous mixture. The prepared SNEDDS was evaluated regarding its appearance, mean droplet size, phase separation, in vitro drug release, and oral bioavailability. Among the screened oil, surfactant, and co-surfactant, Labrafil M 2125 CS, Tween 80, and Transcutol®P mixture exhibited superior solubilizing capacity, respectively. Optimized SNEDDS exhibits 98.39% drug release. SNEDDS dissolution behavior was attributed to oil/surfactant ratios and properties of the surfactant phase. It also demonstrates threefold increments in the area under curve (AUC) in comparison to neat EFV. Furthermore, the optimized SNEDDS does not show any vitrification during its 3-month storage. In the present study, better performance of SNEDDS is explained by various factors like (i) improved surface area of droplets, (ii) superior solubilization potential for hydrophobic drugs due to Labrafil M 2125 CS, and (iii) result of surfactant on mucosal permeability. This study demonstrated that SNEDDS may be an alternative approach for the poorly soluble drugs to improve their solubility and oral bioavailability." @default.
- W2172854955 created "2016-06-24" @default.
- W2172854955 creator A5036438316 @default.
- W2172854955 creator A5038717001 @default.
- W2172854955 creator A5078257314 @default.
- W2172854955 date "2015-11-16" @default.
- W2172854955 modified "2023-10-12" @default.
- W2172854955 title "Efavirenz Self-Nano-Emulsifying Drug Delivery System: In Vitro and In Vivo Evaluation" @default.
- W2172854955 cites W1967773336 @default.
- W2172854955 cites W1974008347 @default.
- W2172854955 cites W1977423002 @default.
- W2172854955 cites W2015765815 @default.
- W2172854955 cites W2033799761 @default.
- W2172854955 cites W2041016731 @default.
- W2172854955 cites W2045956856 @default.
- W2172854955 cites W2049820231 @default.
- W2172854955 cites W2050648235 @default.
- W2172854955 cites W2055941623 @default.
- W2172854955 cites W2064910281 @default.
- W2172854955 cites W2066927092 @default.
- W2172854955 cites W2076863626 @default.
- W2172854955 cites W2083067873 @default.
- W2172854955 cites W2085769595 @default.
- W2172854955 cites W2124040992 @default.
- W2172854955 cites W2127380123 @default.
- W2172854955 cites W2141566507 @default.
- W2172854955 cites W2145295111 @default.
- W2172854955 cites W2161558889 @default.
- W2172854955 cites W2166547808 @default.
- W2172854955 doi "https://doi.org/10.1208/s12249-015-0446-2" @default.
- W2172854955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26573159" @default.
- W2172854955 hasPublicationYear "2015" @default.
- W2172854955 type Work @default.
- W2172854955 sameAs 2172854955 @default.
- W2172854955 citedByCount "46" @default.
- W2172854955 countsByYear W21728549552016 @default.
- W2172854955 countsByYear W21728549552017 @default.
- W2172854955 countsByYear W21728549552018 @default.
- W2172854955 countsByYear W21728549552019 @default.
- W2172854955 countsByYear W21728549552020 @default.
- W2172854955 countsByYear W21728549552021 @default.
- W2172854955 countsByYear W21728549552022 @default.
- W2172854955 countsByYear W21728549552023 @default.
- W2172854955 crossrefType "journal-article" @default.
- W2172854955 hasAuthorship W2172854955A5036438316 @default.
- W2172854955 hasAuthorship W2172854955A5038717001 @default.
- W2172854955 hasAuthorship W2172854955A5078257314 @default.
- W2172854955 hasBestOaLocation W21728549551 @default.
- W2172854955 hasConcept C155574463 @default.
- W2172854955 hasConcept C178790620 @default.
- W2172854955 hasConcept C181389837 @default.
- W2172854955 hasConcept C185592680 @default.
- W2172854955 hasConcept C2779820397 @default.
- W2172854955 hasConcept C2780035454 @default.
- W2172854955 hasConcept C43617362 @default.
- W2172854955 hasConcept C55493867 @default.
- W2172854955 hasConcept C58226133 @default.
- W2172854955 hasConcept C71924100 @default.
- W2172854955 hasConcept C88380143 @default.
- W2172854955 hasConcept C98274493 @default.
- W2172854955 hasConceptScore W2172854955C155574463 @default.
- W2172854955 hasConceptScore W2172854955C178790620 @default.
- W2172854955 hasConceptScore W2172854955C181389837 @default.
- W2172854955 hasConceptScore W2172854955C185592680 @default.
- W2172854955 hasConceptScore W2172854955C2779820397 @default.
- W2172854955 hasConceptScore W2172854955C2780035454 @default.
- W2172854955 hasConceptScore W2172854955C43617362 @default.
- W2172854955 hasConceptScore W2172854955C55493867 @default.
- W2172854955 hasConceptScore W2172854955C58226133 @default.
- W2172854955 hasConceptScore W2172854955C71924100 @default.
- W2172854955 hasConceptScore W2172854955C88380143 @default.
- W2172854955 hasConceptScore W2172854955C98274493 @default.
- W2172854955 hasIssue "5" @default.
- W2172854955 hasLocation W21728549551 @default.
- W2172854955 hasLocation W21728549552 @default.
- W2172854955 hasOpenAccess W2172854955 @default.
- W2172854955 hasPrimaryLocation W21728549551 @default.
- W2172854955 hasRelatedWork W1505739641 @default.
- W2172854955 hasRelatedWork W2027491976 @default.
- W2172854955 hasRelatedWork W2044251933 @default.
- W2172854955 hasRelatedWork W2046280088 @default.
- W2172854955 hasRelatedWork W2073177056 @default.
- W2172854955 hasRelatedWork W2091620391 @default.
- W2172854955 hasRelatedWork W2099575842 @default.
- W2172854955 hasRelatedWork W2110192055 @default.
- W2172854955 hasRelatedWork W230338489 @default.
- W2172854955 hasRelatedWork W2567358723 @default.
- W2172854955 hasVolume "17" @default.
- W2172854955 isParatext "false" @default.
- W2172854955 isRetracted "false" @default.
- W2172854955 magId "2172854955" @default.
- W2172854955 workType "article" @default.