Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172863071> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2172863071 endingPage "e0142161" @default.
- W2172863071 startingPage "e0142161" @default.
- W2172863071 abstract "Anti-apoptotic protein Lifeguard (LFG) is upregulated on T cells upon in vitro activation. To investigate its role in T cell immunity we infected wild type and LFG knockout bone marrow chimaeras mice with LCMV. We observed a decreased number of LFG KO activated CD8 and CD4 T cells throughout the infection and a marked decrease in LFG KO LCMV specific memory T cells. WT and KO T cells proliferated at the same rate, however, LFG KO CD44hi T cells showed increased cell death during the initial phase of the immune response. LFG KO and WT T cells were equally sensitive to the FAS antibody Jo-2 in ex vivo cultures, and blocking extrinsic pathways of cell death in vivo with Fas L or caspase 8 inhibitors did not rescue the increased apoptosis in LFG KO T cells. Our data suggest that LFG plays a role in T cell survival during the initial phase of anti-viral immune response by protecting pre-existing memory T cells and possibly newly activated T cells resulting in a diminished immune response and a decreased number of LCMV specific memory T cells." @default.
- W2172863071 created "2016-06-24" @default.
- W2172863071 creator A5006429267 @default.
- W2172863071 creator A5048279362 @default.
- W2172863071 creator A5088266291 @default.
- W2172863071 date "2015-11-13" @default.
- W2172863071 modified "2023-09-30" @default.
- W2172863071 title "Antiapoptotic Role for Lifeguard in T Cell Mediated Immune Response" @default.
- W2172863071 cites W1967146210 @default.
- W2172863071 cites W1969231504 @default.
- W2172863071 cites W1993695522 @default.
- W2172863071 cites W1996952569 @default.
- W2172863071 cites W2014097269 @default.
- W2172863071 cites W2035021611 @default.
- W2172863071 cites W2061899137 @default.
- W2172863071 cites W2086090484 @default.
- W2172863071 cites W2086759245 @default.
- W2172863071 cites W2102859042 @default.
- W2172863071 cites W2114119059 @default.
- W2172863071 cites W2126168881 @default.
- W2172863071 doi "https://doi.org/10.1371/journal.pone.0142161" @default.
- W2172863071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4643990" @default.
- W2172863071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26565411" @default.
- W2172863071 hasPublicationYear "2015" @default.
- W2172863071 type Work @default.
- W2172863071 sameAs 2172863071 @default.
- W2172863071 citedByCount "2" @default.
- W2172863071 countsByYear W21728630712017 @default.
- W2172863071 countsByYear W21728630712023 @default.
- W2172863071 crossrefType "journal-article" @default.
- W2172863071 hasAuthorship W2172863071A5006429267 @default.
- W2172863071 hasAuthorship W2172863071A5048279362 @default.
- W2172863071 hasAuthorship W2172863071A5088266291 @default.
- W2172863071 hasBestOaLocation W21728630711 @default.
- W2172863071 hasConcept C153911025 @default.
- W2172863071 hasConcept C154317977 @default.
- W2172863071 hasConcept C167672396 @default.
- W2172863071 hasConcept C190283241 @default.
- W2172863071 hasConcept C202751555 @default.
- W2172863071 hasConcept C203014093 @default.
- W2172863071 hasConcept C2776090121 @default.
- W2172863071 hasConcept C31573885 @default.
- W2172863071 hasConcept C55493867 @default.
- W2172863071 hasConcept C86803240 @default.
- W2172863071 hasConcept C8891405 @default.
- W2172863071 hasConcept C95444343 @default.
- W2172863071 hasConceptScore W2172863071C153911025 @default.
- W2172863071 hasConceptScore W2172863071C154317977 @default.
- W2172863071 hasConceptScore W2172863071C167672396 @default.
- W2172863071 hasConceptScore W2172863071C190283241 @default.
- W2172863071 hasConceptScore W2172863071C202751555 @default.
- W2172863071 hasConceptScore W2172863071C203014093 @default.
- W2172863071 hasConceptScore W2172863071C2776090121 @default.
- W2172863071 hasConceptScore W2172863071C31573885 @default.
- W2172863071 hasConceptScore W2172863071C55493867 @default.
- W2172863071 hasConceptScore W2172863071C86803240 @default.
- W2172863071 hasConceptScore W2172863071C8891405 @default.
- W2172863071 hasConceptScore W2172863071C95444343 @default.
- W2172863071 hasIssue "11" @default.
- W2172863071 hasLocation W21728630711 @default.
- W2172863071 hasLocation W21728630712 @default.
- W2172863071 hasLocation W21728630713 @default.
- W2172863071 hasLocation W21728630714 @default.
- W2172863071 hasOpenAccess W2172863071 @default.
- W2172863071 hasPrimaryLocation W21728630711 @default.
- W2172863071 hasRelatedWork W1505145311 @default.
- W2172863071 hasRelatedWork W1513178816 @default.
- W2172863071 hasRelatedWork W1987695408 @default.
- W2172863071 hasRelatedWork W2008479527 @default.
- W2172863071 hasRelatedWork W2018916009 @default.
- W2172863071 hasRelatedWork W2052937977 @default.
- W2172863071 hasRelatedWork W2061297480 @default.
- W2172863071 hasRelatedWork W2153742280 @default.
- W2172863071 hasRelatedWork W2287738525 @default.
- W2172863071 hasRelatedWork W2931523797 @default.
- W2172863071 hasVolume "10" @default.
- W2172863071 isParatext "false" @default.
- W2172863071 isRetracted "false" @default.
- W2172863071 magId "2172863071" @default.
- W2172863071 workType "article" @default.