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- W2173048202 endingPage "459" @default.
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- W2173048202 abstract "During the last 30 years, investigation of the transcriptional and translational mechanisms of gene regulation has been a major focus of molecular cancer biology. More recently, it has become evident that cancer-related mutations and cancer-related therapies also can affect post-translational processing of cellular proteins and that control exerted at this level can be critical in defining both the cancer phenotype and the response to therapeutic intervention. One post-translational mechanism that is receiving considerable attention is degradation of intracellular proteins through the multicatalytic 26S proteasome. This follows growing recognition of the fact that protein degradation is a well-regulated and selective process that can differentially control intracellular protein expression levels. The proteasome is responsible for the degradation of all short-lived proteins and 70-90% of all long-lived proteins, thereby regulating signal transduction through pathways involving factors such as AP1 and NFKB, and processes such as cell cycle progression and arrest, DNA transcription, DNA repair/misrepair, angiogenesis, apoptosis/survival, growth and development, and inflammation and immunity, as well as muscle wasting (e.g. in cachexia and sepsis). In this review, we discuss the potential involvement of the proteasome in both cancer biology and cancer treatment." @default.
- W2173048202 created "2016-06-24" @default.
- W2173048202 creator A5039693749 @default.
- W2173048202 creator A5044488631 @default.
- W2173048202 date "2001-11-01" @default.
- W2173048202 modified "2023-10-13" @default.
- W2173048202 title "The Proteasome in Cancer Biology and Treatment" @default.
- W2173048202 cites W114109640 @default.
- W2173048202 cites W114892145 @default.
- W2173048202 cites W119139793 @default.
- W2173048202 cites W1484582783 @default.
- W2173048202 cites W1519096021 @default.
- W2173048202 cites W151946969 @default.
- W2173048202 cites W1604235714 @default.
- W2173048202 cites W1665769011 @default.
- W2173048202 cites W1749022239 @default.
- W2173048202 cites W1799809595 @default.
- W2173048202 cites W1895274687 @default.
- W2173048202 cites W1928813052 @default.
- W2173048202 cites W1938893963 @default.
- W2173048202 cites W1963542053 @default.
- W2173048202 cites W1965718518 @default.
- W2173048202 cites W1968034628 @default.
- W2173048202 cites W1968495382 @default.
- W2173048202 cites W1969668210 @default.
- W2173048202 cites W1970235416 @default.
- W2173048202 cites W1970523540 @default.
- W2173048202 cites W1973422080 @default.
- W2173048202 cites W1974012392 @default.
- W2173048202 cites W1974134284 @default.
- W2173048202 cites W1975260251 @default.
- W2173048202 cites W1976582166 @default.
- W2173048202 cites W1977312224 @default.
- W2173048202 cites W1978161834 @default.
- W2173048202 cites W1981654235 @default.
- W2173048202 cites W1983501834 @default.
- W2173048202 cites W1987234748 @default.
- W2173048202 cites W1988620153 @default.
- W2173048202 cites W1988622703 @default.
- W2173048202 cites W1990588284 @default.
- W2173048202 cites W1991843895 @default.
- W2173048202 cites W1993983676 @default.
- W2173048202 cites W1994975139 @default.
- W2173048202 cites W1996070675 @default.
- W2173048202 cites W1996449685 @default.
- W2173048202 cites W1997435189 @default.
- W2173048202 cites W1999523595 @default.
- W2173048202 cites W2000309947 @default.
- W2173048202 cites W2000367646 @default.
- W2173048202 cites W2001314409 @default.
- W2173048202 cites W2003623971 @default.
- W2173048202 cites W2004416275 @default.
- W2173048202 cites W2005207160 @default.
- W2173048202 cites W2005768995 @default.
- W2173048202 cites W2005769071 @default.
- W2173048202 cites W2006874274 @default.
- W2173048202 cites W2010174826 @default.
- W2173048202 cites W2010601153 @default.
- W2173048202 cites W2010687882 @default.
- W2173048202 cites W2014519647 @default.
- W2173048202 cites W2015085861 @default.
- W2173048202 cites W2015815772 @default.
- W2173048202 cites W2018434227 @default.
- W2173048202 cites W2018702066 @default.
- W2173048202 cites W2018874336 @default.
- W2173048202 cites W2022638530 @default.
- W2173048202 cites W2023520535 @default.
- W2173048202 cites W2024251179 @default.
- W2173048202 cites W2026632566 @default.
- W2173048202 cites W2027091452 @default.
- W2173048202 cites W2027260180 @default.
- W2173048202 cites W2030117595 @default.
- W2173048202 cites W2032330155 @default.
- W2173048202 cites W2034277114 @default.
- W2173048202 cites W2037612991 @default.
- W2173048202 cites W2039893692 @default.
- W2173048202 cites W2040031153 @default.
- W2173048202 cites W2040202840 @default.
- W2173048202 cites W2040470926 @default.
- W2173048202 cites W2041445228 @default.
- W2173048202 cites W2041759064 @default.
- W2173048202 cites W2041850341 @default.
- W2173048202 cites W2042260090 @default.
- W2173048202 cites W2046302025 @default.
- W2173048202 cites W2049546697 @default.
- W2173048202 cites W2049836993 @default.
- W2173048202 cites W2052025279 @default.
- W2173048202 cites W2052267264 @default.
- W2173048202 cites W2054446345 @default.
- W2173048202 cites W2054668558 @default.
- W2173048202 cites W2055768182 @default.
- W2173048202 cites W2056321966 @default.
- W2173048202 cites W2060860860 @default.
- W2173048202 cites W2062062164 @default.
- W2173048202 cites W2063266560 @default.
- W2173048202 cites W2066437073 @default.
- W2173048202 cites W2067524077 @default.
- W2173048202 cites W2067794232 @default.