Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173124796> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2173124796 endingPage "5002" @default.
- W2173124796 startingPage "4999" @default.
- W2173124796 abstract "A series of estrone conjugates of the type estrone-3-O-C(O,S)-X have been prepared and evaluated for inhibition of human steroid sulfatase (STS). Among the carbamate (6), thiocarbamate (8), cyanate (7), formate (9), and acetate (10) analogs of estrone, only 9 was found to inhibit STS in a time- and concentration-dependent manner. With an IC50 of 0.42 μM 9 is the first potent inactivator of STS which does not feature the sulfamate group. Furthermore a formate-type inhibitor featuring a benzoxazole moiety in place of the steroid skeleton (14) was prepared, suggesting a general principle of inactivation by the formate group. As the mode of action we propose an immediate transfer of the formyl moiety to a nucleophilic residue in the active site of STS." @default.
- W2173124796 created "2016-06-24" @default.
- W2173124796 creator A5013156466 @default.
- W2173124796 creator A5038950669 @default.
- W2173124796 date "2004-10-01" @default.
- W2173124796 modified "2023-10-18" @default.
- W2173124796 title "Estrone formate: a novel type of irreversible inhibitor of human steroid sulfatase" @default.
- W2173124796 cites W1963596430 @default.
- W2173124796 cites W1964485062 @default.
- W2173124796 cites W1980944838 @default.
- W2173124796 cites W1984437337 @default.
- W2173124796 cites W1991080894 @default.
- W2173124796 cites W2002369985 @default.
- W2173124796 cites W2003148738 @default.
- W2173124796 cites W2005643164 @default.
- W2173124796 cites W2022371026 @default.
- W2173124796 cites W2023240712 @default.
- W2173124796 cites W2031539367 @default.
- W2173124796 cites W2034207827 @default.
- W2173124796 cites W2035890379 @default.
- W2173124796 cites W2037474761 @default.
- W2173124796 cites W2076485216 @default.
- W2173124796 cites W2079426265 @default.
- W2173124796 cites W2080398125 @default.
- W2173124796 cites W2346767889 @default.
- W2173124796 cites W2074096796 @default.
- W2173124796 cites W2090700263 @default.
- W2173124796 doi "https://doi.org/10.1016/j.bmcl.2004.07.013" @default.
- W2173124796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15341968" @default.
- W2173124796 hasPublicationYear "2004" @default.
- W2173124796 type Work @default.
- W2173124796 sameAs 2173124796 @default.
- W2173124796 citedByCount "13" @default.
- W2173124796 countsByYear W21731247962013 @default.
- W2173124796 countsByYear W21731247962016 @default.
- W2173124796 countsByYear W21731247962019 @default.
- W2173124796 countsByYear W21731247962020 @default.
- W2173124796 countsByYear W21731247962023 @default.
- W2173124796 crossrefType "journal-article" @default.
- W2173124796 hasAuthorship W2173124796A5013156466 @default.
- W2173124796 hasAuthorship W2173124796A5038950669 @default.
- W2173124796 hasConcept C161790260 @default.
- W2173124796 hasConcept C185592680 @default.
- W2173124796 hasConcept C2776568683 @default.
- W2173124796 hasConcept C2778090324 @default.
- W2173124796 hasConcept C2778656385 @default.
- W2173124796 hasConcept C2780178953 @default.
- W2173124796 hasConcept C2780902042 @default.
- W2173124796 hasConcept C55493867 @default.
- W2173124796 hasConcept C71240020 @default.
- W2173124796 hasConcept C71315377 @default.
- W2173124796 hasConceptScore W2173124796C161790260 @default.
- W2173124796 hasConceptScore W2173124796C185592680 @default.
- W2173124796 hasConceptScore W2173124796C2776568683 @default.
- W2173124796 hasConceptScore W2173124796C2778090324 @default.
- W2173124796 hasConceptScore W2173124796C2778656385 @default.
- W2173124796 hasConceptScore W2173124796C2780178953 @default.
- W2173124796 hasConceptScore W2173124796C2780902042 @default.
- W2173124796 hasConceptScore W2173124796C55493867 @default.
- W2173124796 hasConceptScore W2173124796C71240020 @default.
- W2173124796 hasConceptScore W2173124796C71315377 @default.
- W2173124796 hasIssue "19" @default.
- W2173124796 hasLocation W21731247961 @default.
- W2173124796 hasLocation W21731247962 @default.
- W2173124796 hasOpenAccess W2173124796 @default.
- W2173124796 hasPrimaryLocation W21731247961 @default.
- W2173124796 hasRelatedWork W1569312678 @default.
- W2173124796 hasRelatedWork W1598751430 @default.
- W2173124796 hasRelatedWork W2020847754 @default.
- W2173124796 hasRelatedWork W2042116997 @default.
- W2173124796 hasRelatedWork W2077224086 @default.
- W2173124796 hasRelatedWork W2096977374 @default.
- W2173124796 hasRelatedWork W2105502801 @default.
- W2173124796 hasRelatedWork W2167832548 @default.
- W2173124796 hasRelatedWork W2173124796 @default.
- W2173124796 hasRelatedWork W2949520817 @default.
- W2173124796 hasVolume "14" @default.
- W2173124796 isParatext "false" @default.
- W2173124796 isRetracted "false" @default.
- W2173124796 magId "2173124796" @default.
- W2173124796 workType "article" @default.