FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173228577> ?p ?o ?g. }

• W2173228577 endingPage "1214" @default.
• W2173228577 startingPage "1213" @default.
• W2173228577 abstract "Saager et al.1 used a methodology combining electronic search strategies and clinical adjudication to retrospectively determine the incidence of intraoperative hypersensitivity events in one U.S. surgical center. The authors concluded that the overall incidence of anaphylaxis was 1 in 4,583 surgeries, whereas that of hypersensitivity was 1 in 677. However, major methodologic issues should be highlighted, and the results must be debated because no conclusion can be effectively drawn from this study.First, the claim that “the overall incidence of anaphylaxis was similar to that reported in previous studies but that of hypersensitivity reactions was nearly seven times higher”1 is not accurate because this has not been proved. In addition, it is supposed that hypersensitivity was used to designate immediate hypersensitivity because delayed hypersensitivity does not arise during the perioperative period. Thus, six types of criteria were arbitrarily selected to identify potential perioperative hypersensitivity in 178,746 surgeries during the 7-yr study period. The adjudication committee further selected 264 cases of immediate hypersensitivity corresponding to 7% of the study population by 1, 2, 3, or 4 search criteria and subsequently classified these cases according to a modified Ring and Messmer scale. The search criteria included clinical features, biologic measurements, e.g., histamine, tryptase, or IgE (total or specific), and selected preferred terms. Some of these latter should not have been used because they are not consistent with immediate hypersensitivity. Particularly, the first-use syndrome has been described during hemodialysis2; fixed eruption and drug dermatitis belong to cell-mediated hypersensitivity that has a delayed presentation3; and flushing, sensation of foreign body, and laryngospasm or stridor do not belong to perioperative immediate hypersensitivity per se.4 Therefore, it is unclear whether only clinical features related to perioperative immediate hypersensitivity4 were considered for including the 264 cases. In addition, the timing between the introduction of the suspected trigger and the onset of clinical features is lacking. Accordingly, the onset delay is a useful argument in the diagnostic approach of perioperative immediate hypersensitivity, which usually occurs within minutes, even 1 min, of anesthetic induction.4Second, laboratory tests were performed in only five patients (1.7%) but unfortunately remained undetailed. One should keep in mind that tryptase increase is highly suggestive of mast cell activation as seen in anaphylaxis.4–7 In contrast, total IgE has no indication in the diagnostic approach of perioperative immediate hypersensitivity,7 whereas the identification of serum IgE to quaternary ammonium provides possible evidence of IgE sensitization but does not prove that a neuromuscular-blocking agent elicited the immediate reaction per se.4,6,8Third, skin testing was not performed, and thus, none of these 264 cases can be considered to be definitively supported by an appropriate allergologic assessment. The analysis of biologic and skin tests results should always be tied to a careful and complete review of the clinical history to identify the culprit agent and the pathophysiologic mechanism involved (allergic vs. nonallergic).5–7Fourth, thus, we respectfully disagree with the authors who claim that “the use of neuromuscular blocking agents was not significantly associated with experiencing hypersensitivity reactions” because this has not been demonstrated. Neuromuscular-blocking agents and antibiotics (e.g., β-lactam drugs) still remain the main triggers involved in cases of perioperative anaphylaxis, whereas latex-induced allergy is now becoming less common.4,9 Furthermore, only a few cases of anaphylaxis to hetastarch are reported worldwide,9 and this is not consistent with the statement that “high-molecular-weight hetastarch was significantly associated with hypersensitivity reactions.”In conclusion, the methodology used by Saager et al.1 is not suitable for evaluating perioperative immediate hypersensitivity because none of the 264 cases can be considered to be definitively supported by an appropriate allergologic assessment as recommended by the current guidelines.5–7 In contrast, unfortunately, no conclusion can be drawn from this retrospective study.Dr. Dewachter received payment for lectures, accommodations, and travel fees by MSD France (Courbevoie, France). The other author declares no competing interests." @default.
• W2173228577 created "2016-06-24" @default.
• W2173228577 creator A5061736448 @default.
• W2173228577 creator A5067560656 @default.
• W2173228577 date "2015-11-01" @default.
• W2173228577 modified "2023-09-25" @default.
• W2173228577 title "Incidence of Intraoperative Hypersensitivity Reactions: What’s This About?" @default.
• W2173228577 cites W1598249639 @default.
• W2173228577 cites W1975094261 @default.
• W2173228577 cites W1978276472 @default.
• W2173228577 cites W2009578062 @default.
• W2173228577 cites W2018318330 @default.
• W2173228577 cites W2101449773 @default.
• W2173228577 cites W2124156254 @default.
• W2173228577 doi "https://doi.org/10.1097/aln.0000000000000879" @default.
• W2173228577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26485628" @default.
• W2173228577 hasPublicationYear "2015" @default.
• W2173228577 type Work @default.
• W2173228577 sameAs 2173228577 @default.
• W2173228577 citedByCount "2" @default.
• W2173228577 countsByYear W21732285772016 @default.
• W2173228577 crossrefType "journal-article" @default.
• W2173228577 hasAuthorship W2173228577A5061736448 @default.
• W2173228577 hasAuthorship W2173228577A5067560656 @default.
• W2173228577 hasBestOaLocation W21732285771 @default.
• W2173228577 hasConcept C120665830 @default.
• W2173228577 hasConcept C121332964 @default.
• W2173228577 hasConcept C141071460 @default.
• W2173228577 hasConcept C16005928 @default.
• W2173228577 hasConcept C203014093 @default.
• W2173228577 hasConcept C207480886 @default.
• W2173228577 hasConcept C2775933838 @default.
• W2173228577 hasConcept C2779060952 @default.
• W2173228577 hasConcept C2779726688 @default.
• W2173228577 hasConcept C2781406822 @default.
• W2173228577 hasConcept C2908647359 @default.
• W2173228577 hasConcept C2993280485 @default.
• W2173228577 hasConcept C31174226 @default.
• W2173228577 hasConcept C61511704 @default.
• W2173228577 hasConcept C71924100 @default.
• W2173228577 hasConcept C99454951 @default.
• W2173228577 hasConceptScore W2173228577C120665830 @default.
• W2173228577 hasConceptScore W2173228577C121332964 @default.
• W2173228577 hasConceptScore W2173228577C141071460 @default.
• W2173228577 hasConceptScore W2173228577C16005928 @default.
• W2173228577 hasConceptScore W2173228577C203014093 @default.
• W2173228577 hasConceptScore W2173228577C207480886 @default.
• W2173228577 hasConceptScore W2173228577C2775933838 @default.
• W2173228577 hasConceptScore W2173228577C2779060952 @default.
• W2173228577 hasConceptScore W2173228577C2779726688 @default.
• W2173228577 hasConceptScore W2173228577C2781406822 @default.
• W2173228577 hasConceptScore W2173228577C2908647359 @default.
• W2173228577 hasConceptScore W2173228577C2993280485 @default.
• W2173228577 hasConceptScore W2173228577C31174226 @default.
• W2173228577 hasConceptScore W2173228577C61511704 @default.
• W2173228577 hasConceptScore W2173228577C71924100 @default.
• W2173228577 hasConceptScore W2173228577C99454951 @default.
• W2173228577 hasIssue "5" @default.
• W2173228577 hasLocation W21732285771 @default.
• W2173228577 hasLocation W21732285772 @default.
• W2173228577 hasOpenAccess W2173228577 @default.
• W2173228577 hasPrimaryLocation W21732285771 @default.
• W2173228577 hasRelatedWork W1906382642 @default.
• W2173228577 hasRelatedWork W2074945661 @default.
• W2173228577 hasRelatedWork W2092665604 @default.
• W2173228577 hasRelatedWork W2103640113 @default.
• W2173228577 hasRelatedWork W2618296311 @default.
• W2173228577 hasRelatedWork W3023710645 @default.
• W2173228577 hasRelatedWork W3032303464 @default.
• W2173228577 hasRelatedWork W3035986814 @default.
• W2173228577 hasRelatedWork W4220753998 @default.
• W2173228577 hasRelatedWork W4280546142 @default.
• W2173228577 hasVolume "123" @default.
• W2173228577 isParatext "false" @default.
• W2173228577 isRetracted "false" @default.
• W2173228577 magId "2173228577" @default.
• W2173228577 workType "article" @default.