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- W2173249899 abstract "A novel potent and selective aminophenol scaffold for fXa inhibitors was developed from a previously reported benzimidazole-based naphthylamidine template. The aminophenol template is more synthetically accessible than the benzimidazole template, which simplified the introduction of carboxylic acid groups. Substitution of a propenyl-para-hydroxy-benzamidine group on the aminophenol template produced selective, sub-nanomolar fXa inhibitors. The potency of the inhibitors is partially explained with the aid of a trypsin complex crystal structure." @default.
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- W2173249899 date "2002-05-01" @default.
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- W2173249899 title "Design and synthesis of aminophenol-Based factor xa inhibitors" @default.
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- W2173249899 doi "https://doi.org/10.1016/s0960-894x(02)00142-7" @default.
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