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- W2173313663 abstract "Extensively drug-resistant (XDR) tuberculosis is becoming increasingly prevalent worldwide, but little is known about XDR tuberculosis in young children. In this Grand Round we describe a 2-year-old child from the USA who developed pneumonia after a 3 month visit to India. Symptoms resolved with empirical first-line tuberculosis treatment; however, a XDR strain of Mycobacterium tuberculosis grew in culture. In the absence of clinical or microbiological markers, low-radiation exposure pulmonary CT imaging was used to monitor treatment response, and guide an individualised drug regimen. Management was complicated by delays in diagnosis, uncertainties about drug selection, and a scarcity of child-friendly formulations. Treatment has been successful so far, and the child is in remission. This report of XDR tuberculosis in a young child in the USA highlights the risks of acquiring drug-resistant tuberculosis overseas, and the unique challenges in management of tuberculosis in this susceptible population." @default.
- W2173313663 created "2016-06-24" @default.
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- W2173313663 date "2015-12-01" @default.
- W2173313663 modified "2023-09-27" @default.
- W2173313663 title "Extensively drug-resistant tuberculosis in a young child after travel to India" @default.
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- W2173313663 doi "https://doi.org/10.1016/s1473-3099(15)00356-4" @default.
- W2173313663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4843989" @default.
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- W2173313663 hasPublicationYear "2015" @default.
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