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• W2173346413 abstract "The previous article in this review dealing with the regulatory properties of brain tyrosine (TOH) and tryptophan hydroxylase (TPOH) systems (1 ) empha­ sized (a) multidimensional ity: almost all the components present under phys ­ iological and assay conditions, ranging from electromagnetic fields through hydrophobic ligands to reducing equivalents, influence in one way or another the rate functions representing catalytic activities; (b) nonlinearity: critical zones of ligand concentration, curvilinear, even intermittent amount-effect functions, and inconsistencies among results depending on small differences in parameter values are consonant with the prominent role of cooperative interac­ tions among the many stated and unstated dimensions (coordinates) regulating catalytic systems; (c) conformational instability: in the protein macromolecular components of TOH and TPOH, conformational instabilities are evidenced by 20 years offailure to purify the enzyme proteins in amounts useful for systemat­ ic extensive kinetic characterization , by their extreme friability under condi­ tions of storage, by their multiplicity of reported molecular weigh ts and kinetic constants, and by their markedly increased ease of denaturation and precipita­ tion after the removal of components from their normal milieu by dialysis and enrichment procedures. That article expressed hope that a multivariate approach to studies of TOH and TPOH regulation could be developed to allow data reduction through pattern analysis in place of one-or two-variable kinetic experiments and quantification by Michaelis or Hill constants (1 ). This review updates the 1978 one with respect to research on the regulatory properties of TOH and TPOH as reported in the literature through early 1983 with the exception of the cyclic nucleotide-prote in phosphorylati on schemata (recently involving calmodulin), the current status of which is reviewed else" @default.
• W2173346413 created "2016-06-24" @default.
• W2173346413 creator A5072784821 @default.
• W2173346413 date "1984-04-01" @default.
• W2173346413 modified "2023-09-23" @default.
• W2173346413 title "Non-Equilibrium Behavior of Some Brain Enzyme and Receptor Systems" @default.
• W2173346413 cites W102601851 @default.
• W2173346413 cites W1499408335 @default.
• W2173346413 cites W157808733 @default.
• W2173346413 cites W1578301002 @default.
• W2173346413 cites W1591030847 @default.
• W2173346413 cites W1605648388 @default.
• W2173346413 cites W1858874412 @default.
• W2173346413 cites W1969324628 @default.
• W2173346413 cites W1971842245 @default.
• W2173346413 cites W1976116089 @default.
• W2173346413 cites W1982581996 @default.
• W2173346413 cites W1984368386 @default.
• W2173346413 cites W1987435783 @default.
• W2173346413 cites W1988385174 @default.
• W2173346413 cites W1989901803 @default.
• W2173346413 cites W1989916519 @default.
• W2173346413 cites W1991946161 @default.
• W2173346413 cites W1993187009 @default.
• W2173346413 cites W1993241875 @default.
• W2173346413 cites W1993552283 @default.
• W2173346413 cites W1994774629 @default.
• W2173346413 cites W1997089637 @default.
• W2173346413 cites W1999639713 @default.
• W2173346413 cites W2001380419 @default.
• W2173346413 cites W2001738247 @default.
• W2173346413 cites W2005097301 @default.
• W2173346413 cites W2012732366 @default.
• W2173346413 cites W2015144460 @default.
• W2173346413 cites W2018507678 @default.
• W2173346413 cites W2022542365 @default.
• W2173346413 cites W2022761661 @default.
• W2173346413 cites W2024213285 @default.
• W2173346413 cites W2027980166 @default.
• W2173346413 cites W2029071561 @default.
• W2173346413 cites W2031634775 @default.
• W2173346413 cites W2032351527 @default.
• W2173346413 cites W2033597508 @default.
• W2173346413 cites W2036632234 @default.
• W2173346413 cites W2040355223 @default.
• W2173346413 cites W2042934054 @default.
• W2173346413 cites W2051382440 @default.
• W2173346413 cites W2056324472 @default.
• W2173346413 cites W2057725254 @default.
• W2173346413 cites W2064502281 @default.
• W2173346413 cites W2065858822 @default.
• W2173346413 cites W2074983105 @default.
• W2173346413 cites W2075017839 @default.
• W2173346413 cites W2075248661 @default.
• W2173346413 cites W2076168751 @default.
• W2173346413 cites W2077235131 @default.
• W2173346413 cites W2079384663 @default.
• W2173346413 cites W2079722759 @default.
• W2173346413 cites W2083701492 @default.
• W2173346413 cites W2085188728 @default.
• W2173346413 cites W2087844845 @default.
• W2173346413 cites W2090949058 @default.
• W2173346413 cites W2093810427 @default.
• W2173346413 cites W2094108392 @default.
• W2173346413 cites W2094294218 @default.
• W2173346413 cites W2100053906 @default.
• W2173346413 cites W2102240131 @default.
• W2173346413 cites W2102787760 @default.
• W2173346413 cites W2115105023 @default.
• W2173346413 cites W2124117567 @default.
• W2173346413 cites W2131151226 @default.
• W2173346413 cites W2143941435 @default.
• W2173346413 cites W2146904216 @default.
• W2173346413 cites W2158787087 @default.
• W2173346413 cites W2173914940 @default.
• W2173346413 cites W2174979179 @default.
• W2173346413 cites W2176845524 @default.
• W2173346413 cites W2190501525 @default.
• W2173346413 cites W2247672865 @default.
• W2173346413 cites W2288976819 @default.
• W2173346413 cites W2293524999 @default.
• W2173346413 cites W2312450606 @default.
• W2173346413 cites W2320796935 @default.
• W2173346413 cites W2335484446 @default.
• W2173346413 cites W2413222676 @default.
• W2173346413 cites W2443331839 @default.
• W2173346413 cites W2751862591 @default.
• W2173346413 cites W2921371888 @default.
• W2173346413 cites W627126146 @default.
• W2173346413 cites W75327049 @default.
• W2173346413 cites W1991297476 @default.
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• W2173346413 doi "https://doi.org/10.1146/annurev.pa.24.040184.001321" @default.
• W2173346413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6375547" @default.
• W2173346413 hasPublicationYear "1984" @default.
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