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- W2173347118 endingPage "2018" @default.
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- W2173347118 abstract "Aims: To assess the cost–effectiveness of CYP2B6 genotyping to guide efavirenz dosing for initial HIV therapy in the USA. Methods: We used the Cost–Effectiveness of Preventing AIDS Complications (CEPAC) microsimulation model to project quality-adjusted life expectancy and lifetime costs (2014 US dollars) for efavirenz-based HIV therapy with or without CYP2B6 genotyping. We assumed that with genotyping 60% of patients would be eligible to receive lower doses. Results: Current care without CYP2B6 genotyping has an incremental cost–effectiveness ratio >$100,000/QALY compared with genotype-guided dosing, even if lower dosing reduces efficacy. When we assumed generic efavirenz availability, conclusions were similar unless lower dosing reduces efficacy by 6% or more. Conclusion: CYP2B6 genotyping can inform efavirenz dosing and decrease HIV therapy cost." @default.
- W2173347118 created "2016-06-24" @default.
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- W2173347118 date "2015-12-01" @default.
- W2173347118 modified "2023-10-16" @default.
- W2173347118 title "Cost–effectiveness of <i>CYP2B6</i> genotyping to optimize efavirenz dosing in HIV clinical practice" @default.
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- W2173347118 doi "https://doi.org/10.2217/pgs.15.142" @default.
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