Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173444673> ?p ?o ?g. }
- W2173444673 endingPage "665" @default.
- W2173444673 startingPage "655" @default.
- W2173444673 abstract "The fact that the pedunculopontine nucleus (PPN) is part of the reticular activating system places it in a unique position to modulate sensory input and fight-or-flight responses. Arousing stimuli simultaneously activate ascending projections of the PPN to the intralaminar thalamus to trigger cortical high-frequency activity and arousal, as well as descending projections to reticulospinal systems to alter posture and locomotion. As such, the PPN has become a target for deep brain stimulation for the treatment of Parkinson's disease, modulating gait, posture, and higher functions. This article describes the latest discoveries on PPN physiology and the role of the PPN in a number of disorders. It has now been determined that high-frequency activity during waking and REM sleep is controlled by two different intracellular pathways and two calcium channels in PPN cells. Moreover, there are three different PPN cell types that have one or both calcium channels and may be active during waking only, REM sleep only, or both. Based on the new discoveries, novel mechanisms are proposed for insomnia as a waking disorder. In addition, neuronal calcium sensor protein-1 (NCS-1), which is over expressed in schizophrenia and bipolar disorder, may be responsible for the dysregulation in gamma band activity in at least some patients with these diseases. Recent results suggest that NCS-1 modulates PPN gamma band activity and that lithium acts to reduce the effects of over expressed NCS-1, accounting for its effectiveness in bipolar disorder." @default.
- W2173444673 created "2016-06-24" @default.
- W2173444673 creator A5015755370 @default.
- W2173444673 creator A5023479512 @default.
- W2173444673 creator A5029231495 @default.
- W2173444673 creator A5032899260 @default.
- W2173444673 creator A5064721799 @default.
- W2173444673 creator A5091144066 @default.
- W2173444673 date "2015-11-23" @default.
- W2173444673 modified "2023-10-17" @default.
- W2173444673 title "Implications of gamma band activity in the pedunculopontine nucleus" @default.
- W2173444673 cites W108217131 @default.
- W2173444673 cites W1503333289 @default.
- W2173444673 cites W1531970366 @default.
- W2173444673 cites W1712299124 @default.
- W2173444673 cites W1723764352 @default.
- W2173444673 cites W1964072105 @default.
- W2173444673 cites W1966296244 @default.
- W2173444673 cites W1967515685 @default.
- W2173444673 cites W1967952491 @default.
- W2173444673 cites W1970486520 @default.
- W2173444673 cites W1972809394 @default.
- W2173444673 cites W1980500397 @default.
- W2173444673 cites W1981399390 @default.
- W2173444673 cites W1981584486 @default.
- W2173444673 cites W1981587254 @default.
- W2173444673 cites W1981646620 @default.
- W2173444673 cites W1985496076 @default.
- W2173444673 cites W1987491743 @default.
- W2173444673 cites W1992356214 @default.
- W2173444673 cites W1995287676 @default.
- W2173444673 cites W1995752456 @default.
- W2173444673 cites W1996261562 @default.
- W2173444673 cites W1996601784 @default.
- W2173444673 cites W1996874802 @default.
- W2173444673 cites W2000499266 @default.
- W2173444673 cites W2003759697 @default.
- W2173444673 cites W2004370576 @default.
- W2173444673 cites W2005235157 @default.
- W2173444673 cites W2009006606 @default.
- W2173444673 cites W2013139348 @default.
- W2173444673 cites W2013923145 @default.
- W2173444673 cites W2021482304 @default.
- W2173444673 cites W2026834521 @default.
- W2173444673 cites W2028800859 @default.
- W2173444673 cites W2030741278 @default.
- W2173444673 cites W2034450065 @default.
- W2173444673 cites W2034786388 @default.
- W2173444673 cites W2035225641 @default.
- W2173444673 cites W2037555898 @default.
- W2173444673 cites W2037812600 @default.
- W2173444673 cites W2048509568 @default.
- W2173444673 cites W2060426595 @default.
- W2173444673 cites W2060857888 @default.
- W2173444673 cites W2062597018 @default.
- W2173444673 cites W2067697856 @default.
- W2173444673 cites W2074959655 @default.
- W2173444673 cites W2078787956 @default.
- W2173444673 cites W2078842725 @default.
- W2173444673 cites W2079199391 @default.
- W2173444673 cites W2083131147 @default.
- W2173444673 cites W2085319761 @default.
- W2173444673 cites W2089647719 @default.
- W2173444673 cites W2091017278 @default.
- W2173444673 cites W2093473666 @default.
- W2173444673 cites W2095060637 @default.
- W2173444673 cites W2096403396 @default.
- W2173444673 cites W2099855159 @default.
- W2173444673 cites W2105222555 @default.
- W2173444673 cites W2117213785 @default.
- W2173444673 cites W2122349857 @default.
- W2173444673 cites W2125877971 @default.
- W2173444673 cites W2131991500 @default.
- W2173444673 cites W2135266824 @default.
- W2173444673 cites W2160942289 @default.
- W2173444673 cites W2161069702 @default.
- W2173444673 cites W2165277324 @default.
- W2173444673 cites W2170901091 @default.
- W2173444673 cites W2172085609 @default.
- W2173444673 cites W2172513721 @default.
- W2173444673 cites W2187094704 @default.
- W2173444673 cites W2197909407 @default.
- W2173444673 cites W2295654252 @default.
- W2173444673 cites W2332852656 @default.
- W2173444673 cites W330387651 @default.
- W2173444673 doi "https://doi.org/10.1007/s00702-015-1485-2" @default.
- W2173444673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4877293" @default.
- W2173444673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26597124" @default.
- W2173444673 hasPublicationYear "2015" @default.
- W2173444673 type Work @default.
- W2173444673 sameAs 2173444673 @default.
- W2173444673 citedByCount "29" @default.
- W2173444673 countsByYear W21734446732016 @default.
- W2173444673 countsByYear W21734446732017 @default.
- W2173444673 countsByYear W21734446732018 @default.
- W2173444673 countsByYear W21734446732019 @default.
- W2173444673 countsByYear W21734446732020 @default.
- W2173444673 countsByYear W21734446732022 @default.