FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173447488> ?p ?o ?g. }

• W2173447488 endingPage "232" @default.
• W2173447488 startingPage "223" @default.
• W2173447488 abstract "The toll-like receptors (TLRs) are important innate receptors recognizing potentially pathogenic material. However, they also play a significant role in the development of Alzheimer's disease, cancer, autoimmunity and the susceptibility to viral infections. Macrophages are essential for an effective immune response to foreign material and the resolution of inflammation. In these studies, we examined the impact of different TLR ligands on macrophage cell function. We demonstrate that stimulation of all TLRs tested increases the phagocytosis of apoptotic cells by macrophages. TLR7 and TLR9 ligation decreased the levels of the surface co-expression molecules CD86 and MHCII, which was associated with a concomitant reduction in antigen presentation and proliferation of T cells. This down-regulation in macrophage function was not due to an increase in cell death. In fact, exposure to TLR7 or TLR9 ligands promoted cell viability for up to 9 days, in contrast to TLR3 or TLR4. Additionally, macrophages exposed to TLR7/TLR9 ligands had a significantly lower ratio of Il-12/Il-10 mRNA expression compared with those treated with the TLR4 ligand, LPS. Taken together, these data demonstrate that TLR7/TLR9 ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state." @default.
• W2173447488 created "2016-06-24" @default.
• W2173447488 creator A5002758533 @default.
• W2173447488 creator A5006185510 @default.
• W2173447488 creator A5032272395 @default.
• W2173447488 creator A5033557420 @default.
• W2173447488 creator A5042421432 @default.
• W2173447488 creator A5050267398 @default.
• W2173447488 creator A5055004103 @default.
• W2173447488 creator A5056850846 @default.
• W2173447488 creator A5057282202 @default.
• W2173447488 creator A5071896688 @default.
• W2173447488 date "2015-11-13" @default.
• W2173447488 modified "2023-10-14" @default.
• W2173447488 title "TLR7 and TLR9 ligands regulate antigen presentation by macrophages" @default.
• W2173447488 cites W1539335158 @default.
• W2173447488 cites W1569643828 @default.
• W2173447488 cites W174236543 @default.
• W2173447488 cites W1968134126 @default.
• W2173447488 cites W1982727668 @default.
• W2173447488 cites W1985859986 @default.
• W2173447488 cites W1995299599 @default.
• W2173447488 cites W2005443006 @default.
• W2173447488 cites W2016293419 @default.
• W2173447488 cites W2018325317 @default.
• W2173447488 cites W2019954526 @default.
• W2173447488 cites W2024116215 @default.
• W2173447488 cites W2036153647 @default.
• W2173447488 cites W2036767516 @default.
• W2173447488 cites W2054472394 @default.
• W2173447488 cites W2055026444 @default.
• W2173447488 cites W2055620105 @default.
• W2173447488 cites W2056241473 @default.
• W2173447488 cites W2058547224 @default.
• W2173447488 cites W2061123122 @default.
• W2173447488 cites W2072462631 @default.
• W2173447488 cites W2074496192 @default.
• W2173447488 cites W2078941471 @default.
• W2173447488 cites W2093705034 @default.
• W2173447488 cites W2101771134 @default.
• W2173447488 cites W2104501650 @default.
• W2173447488 cites W2105270641 @default.
• W2173447488 cites W2111975769 @default.
• W2173447488 cites W2115267868 @default.
• W2173447488 cites W2118184788 @default.
• W2173447488 cites W2123333870 @default.
• W2173447488 cites W2136437831 @default.
• W2173447488 cites W2138503227 @default.
• W2173447488 cites W2141842993 @default.
• W2173447488 cites W2147596501 @default.
• W2173447488 cites W2151181789 @default.
• W2173447488 cites W2157283041 @default.
• W2173447488 cites W2167381279 @default.
• W2173447488 cites W2168203604 @default.
• W2173447488 cites W2182737623 @default.
• W2173447488 cites W4235300003 @default.
• W2173447488 doi "https://doi.org/10.1093/intimm/dxv066" @default.
• W2173447488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4888346" @default.
• W2173447488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26567289" @default.
• W2173447488 hasPublicationYear "2015" @default.
• W2173447488 type Work @default.
• W2173447488 sameAs 2173447488 @default.
• W2173447488 citedByCount "41" @default.
• W2173447488 countsByYear W21734474882016 @default.
• W2173447488 countsByYear W21734474882017 @default.
• W2173447488 countsByYear W21734474882018 @default.
• W2173447488 countsByYear W21734474882019 @default.
• W2173447488 countsByYear W21734474882020 @default.
• W2173447488 countsByYear W21734474882021 @default.
• W2173447488 countsByYear W21734474882022 @default.
• W2173447488 countsByYear W21734474882023 @default.
• W2173447488 crossrefType "journal-article" @default.
• W2173447488 hasAuthorship W2173447488A5002758533 @default.
• W2173447488 hasAuthorship W2173447488A5006185510 @default.
• W2173447488 hasAuthorship W2173447488A5032272395 @default.
• W2173447488 hasAuthorship W2173447488A5033557420 @default.
• W2173447488 hasAuthorship W2173447488A5042421432 @default.
• W2173447488 hasAuthorship W2173447488A5050267398 @default.
• W2173447488 hasAuthorship W2173447488A5055004103 @default.
• W2173447488 hasAuthorship W2173447488A5056850846 @default.
• W2173447488 hasAuthorship W2173447488A5057282202 @default.
• W2173447488 hasAuthorship W2173447488A5071896688 @default.
• W2173447488 hasBestOaLocation W21734474881 @default.
• W2173447488 hasConcept C104317684 @default.
• W2173447488 hasConcept C111289621 @default.
• W2173447488 hasConcept C136449434 @default.
• W2173447488 hasConcept C150194340 @default.
• W2173447488 hasConcept C185592680 @default.
• W2173447488 hasConcept C190727270 @default.
• W2173447488 hasConcept C202751555 @default.
• W2173447488 hasConcept C203014093 @default.
• W2173447488 hasConcept C2776070231 @default.
• W2173447488 hasConcept C2776090121 @default.
• W2173447488 hasConcept C2776709828 @default.
• W2173447488 hasConcept C2776914184 @default.
• W2173447488 hasConcept C2778420691 @default.
• W2173447488 hasConcept C2779138994 @default.
• W2173447488 hasConcept C2779244956 @default.

• next