FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173463809> ?p ?o ?g. }

• W2173463809 endingPage "44622" @default.
• W2173463809 startingPage "44609" @default.
• W2173463809 abstract "// Rui Zhou 1, * , Xiaoshu Zhou 1, * , Zhongyuan Yin 1 , Jing Guo 2 , Ting Hu 1 , Shun Jiang 3 , Li Liu 1 , Xiaorong Dong 1 , Sheng Zhang 1 , Gang Wu 1 1 Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 2 Department of Oncology of The Affiliated Hospital of Qingdao University, Qingdao, China 3 Department of Oncology, Second Xiangya Hospital of Central South University, Changsha, China * These authors have contributed equally to this work Correspondence to: Gang Wu, e-mail: xhzlwg@163.com Keywords: miR-184, miR-574-5p, metastasis, prognosis, SCLC Received: April 18, 2015      Accepted: November 06, 2015      Published: November 16, 2015 ABSTRACT Small-cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor that has an extremely poor clinical prognosis. Metastasis is the key event in SCLC progression, but its mechanism has not been fully elucidated. MicroRNAs (miRNAs) have been proven to participate in cancer processes, but their function in SCLC has not been thoroughly studied either. Here, we performed microarray and quantitative real-time PCR (qRT-PCR) analysesto identify the miRNAsassociated with metastasis and prognosis in SCLC as well as the correlation between serum and tissue. We also explored these miRNAs’ promising molecular mechanisms by 3′UTR reporter assay and immunoblotting. We showed thatmiR-184 significantly attenuated the metastasis of SCLC, whereas miR-574–5p enhanced it. Both miRNAs were found to participate in β-catenin signaling by suppressing protein tyrosine phosphatase receptor type U (PTPRU)orendothelial PAS domain protein 1 (EPAS1). Furthermore, miR-574–5p was verified as an independent prognostic risk factor for SCLC. Taken together, our findings providea comprehensive analysis of the miRNA expression pattern in SCLC and indicate that miRNAs may serve as potential therapeutic and prognostic predictors in SCLC." @default.
• W2173463809 created "2016-06-24" @default.
• W2173463809 creator A5032823332 @default.
• W2173463809 creator A5047696302 @default.
• W2173463809 creator A5047855118 @default.
• W2173463809 creator A5055330527 @default.
• W2173463809 creator A5063481044 @default.
• W2173463809 creator A5075329922 @default.
• W2173463809 creator A5077703494 @default.
• W2173463809 creator A5080381497 @default.
• W2173463809 creator A5082858886 @default.
• W2173463809 creator A5087973491 @default.
• W2173463809 date "2015-11-16" @default.
• W2173463809 modified "2023-10-13" @default.
• W2173463809 title "Tumor invasion and metastasis regulated by microRNA-184 and microRNA-574-5p in small-cell lung cancer" @default.
• W2173463809 cites W1521811891 @default.
• W2173463809 cites W1969192247 @default.
• W2173463809 cites W1971886895 @default.
• W2173463809 cites W1972371148 @default.
• W2173463809 cites W1974025003 @default.
• W2173463809 cites W1974469992 @default.
• W2173463809 cites W1988024247 @default.
• W2173463809 cites W1989827688 @default.
• W2173463809 cites W1990666076 @default.
• W2173463809 cites W1992329440 @default.
• W2173463809 cites W1998664010 @default.
• W2173463809 cites W2002583205 @default.
• W2173463809 cites W2005154499 @default.
• W2173463809 cites W2006158316 @default.
• W2173463809 cites W2006247279 @default.
• W2173463809 cites W2014311023 @default.
• W2173463809 cites W2022667041 @default.
• W2173463809 cites W2023642368 @default.
• W2173463809 cites W2028625067 @default.
• W2173463809 cites W2039630990 @default.
• W2173463809 cites W2045410673 @default.
• W2173463809 cites W2048374684 @default.
• W2173463809 cites W2050434028 @default.
• W2173463809 cites W2057382530 @default.
• W2173463809 cites W2060863314 @default.
• W2173463809 cites W2075060873 @default.
• W2173463809 cites W2076552604 @default.
• W2173463809 cites W2078771095 @default.
• W2173463809 cites W2079683613 @default.
• W2173463809 cites W2088962068 @default.
• W2173463809 cites W2091665689 @default.
• W2173463809 cites W2095777207 @default.
• W2173463809 cites W2107331555 @default.
• W2173463809 cites W2107648723 @default.
• W2173463809 cites W2108775841 @default.
• W2173463809 cites W2109227959 @default.
• W2173463809 cites W2112094268 @default.
• W2173463809 cites W2113047680 @default.
• W2173463809 cites W2117139716 @default.
• W2173463809 cites W2123292213 @default.
• W2173463809 cites W2132685226 @default.
• W2173463809 cites W2137736267 @default.
• W2173463809 cites W2145617194 @default.
• W2173463809 cites W2148294117 @default.
• W2173463809 cites W2154610459 @default.
• W2173463809 cites W2418293161 @default.
• W2173463809 cites W2580449060 @default.
• W2173463809 cites W152121915 @default.
• W2173463809 doi "https://doi.org/10.18632/oncotarget.6338" @default.
• W2173463809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4792579" @default.
• W2173463809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26587830" @default.
• W2173463809 hasPublicationYear "2015" @default.
• W2173463809 type Work @default.
• W2173463809 sameAs 2173463809 @default.
• W2173463809 citedByCount "41" @default.
• W2173463809 countsByYear W21734638092016 @default.
• W2173463809 countsByYear W21734638092017 @default.
• W2173463809 countsByYear W21734638092018 @default.
• W2173463809 countsByYear W21734638092019 @default.
• W2173463809 countsByYear W21734638092020 @default.
• W2173463809 countsByYear W21734638092021 @default.
• W2173463809 countsByYear W21734638092022 @default.
• W2173463809 countsByYear W21734638092023 @default.
• W2173463809 crossrefType "journal-article" @default.
• W2173463809 hasAuthorship W2173463809A5032823332 @default.
• W2173463809 hasAuthorship W2173463809A5047696302 @default.
• W2173463809 hasAuthorship W2173463809A5047855118 @default.
• W2173463809 hasAuthorship W2173463809A5055330527 @default.
• W2173463809 hasAuthorship W2173463809A5063481044 @default.
• W2173463809 hasAuthorship W2173463809A5075329922 @default.
• W2173463809 hasAuthorship W2173463809A5077703494 @default.
• W2173463809 hasAuthorship W2173463809A5080381497 @default.
• W2173463809 hasAuthorship W2173463809A5082858886 @default.
• W2173463809 hasAuthorship W2173463809A5087973491 @default.
• W2173463809 hasBestOaLocation W21734638091 @default.
• W2173463809 hasConcept C104317684 @default.
• W2173463809 hasConcept C121608353 @default.
• W2173463809 hasConcept C126322002 @default.
• W2173463809 hasConcept C143998085 @default.
• W2173463809 hasConcept C145059251 @default.
• W2173463809 hasConcept C2776256026 @default.
• W2173463809 hasConcept C2779013556 @default.
• W2173463809 hasConcept C502942594 @default.

• next