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• W2173471425 abstract "Abstract Major histocompatibility complex ( MHC ) genes encode proteins that play a critical role in vertebrate immune system and are highly polymorphic. To further understand the molecular evolution of the MHC genes, we compared MHC class II DRB genes between the Japanese weasel ( Mustela itatsi ), a species endemic to Japan, and the Siberian weasel ( Mustela sibirica ), a closely related species on the continent. We sequenced a 242‐bp region of DRB exon 2, which encodes antigen‐binding sites ( ABS ), and found 24 alleles from 31 M. itatsi individuals and 17 alleles from 21 M. sibirica individuals, including broadly distributed, species‐specific and/or geographically restricted alleles. Our results suggest that pathogen‐driven balancing selection have acted to maintain the diversity in the DRB genes. For predicted ABS , nonsynonymous substitutions exceeded synonymous substitutions, also indicating positive selection, which was not seen at non‐ ABS . In a Bayesian phylogenetic tree, two M. sibirica DRB alleles were basal to the rest of the sequences from mustelid species and may represent ancestral alleles. Trans‐species polymorphism was evident between many mustelid DRB alleles, especially between M. itatsi and M. sibirica . These two Mustela species divided about 1.7 million years ago, but still share many MHC alleles, indicative of their close phylogenetic relationship." @default.
• W2173471425 created "2016-06-24" @default.
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• W2173471425 date "2015-11-22" @default.
• W2173471425 modified "2023-10-03" @default.
• W2173471425 title "Genetic variation of the MHC class II DRB genes in the Japanese weasel,<i>Mustela itatsi</i>, endemic to Japan, compared with the Siberian weasel,<i>Mustela sibirica</i>" @default.
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• W2173471425 doi "https://doi.org/10.1111/tan.12700" @default.
• W2173471425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26593752" @default.
• W2173471425 hasPublicationYear "2015" @default.
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