Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173474966> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2173474966 endingPage "109" @default.
- W2173474966 startingPage "101" @default.
- W2173474966 abstract "BRCA1, a breast and ovarian tumor suppressor, maintains genome stability through its functions in DNA repair, cell-cycle checkpoints, heterochromatin formation and centrosome amplification. BRCA1 interacts with BARD1 to constitute a RING heterodimer-type E3 ubiquitin ligase. BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that also regulates similar cellular events, including cell-cycle control, transcription, chromatin modification and DNA damage response. Germline mutations in BRCA1 predispose individuals to breast, ovarian, fallopian tube, peritoneal, pancreatic and prostate cancers, whereas BAP1 mutations combined with certain types of DNA damage provoke malignant mesothelioma, uveal and cutaneous melanoma, lung adenocarcinoma and renal cell carcinoma. Although BAP1 was initially discovered as a BRCA1-associated protein, recent mass-spectrometric screens of BAP1 interactors failed to detect BRCA1, raising questions about their presumed endogenous interaction. However, in addition to physical interaction, new evidence indicates a functional correlation between the two proteins. This review summarizes BAP1 function in histone modification and the DNA damage response, focusing on BAP1's relevance to BRCA1 function. An understanding of the cooperative functions between BRCA1 and BAP1 may uncover opportunities for new drug targets in a variety of related cancers." @default.
- W2173474966 created "2016-06-24" @default.
- W2173474966 creator A5000588962 @default.
- W2173474966 creator A5050276095 @default.
- W2173474966 creator A5060606530 @default.
- W2173474966 creator A5061390674 @default.
- W2173474966 creator A5070744352 @default.
- W2173474966 date "2016-01-05" @default.
- W2173474966 modified "2023-10-05" @default.
- W2173474966 title "Functional Link between BRCA1 and BAP1 through Histone H2A, Heterochromatin and DNA Damage Response" @default.
- W2173474966 doi "https://doi.org/10.2174/1568009615666151030102427" @default.
- W2173474966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26517537" @default.
- W2173474966 hasPublicationYear "2016" @default.
- W2173474966 type Work @default.
- W2173474966 sameAs 2173474966 @default.
- W2173474966 citedByCount "22" @default.
- W2173474966 countsByYear W21734749662016 @default.
- W2173474966 countsByYear W21734749662017 @default.
- W2173474966 countsByYear W21734749662018 @default.
- W2173474966 countsByYear W21734749662019 @default.
- W2173474966 countsByYear W21734749662020 @default.
- W2173474966 countsByYear W21734749662021 @default.
- W2173474966 countsByYear W21734749662022 @default.
- W2173474966 countsByYear W21734749662023 @default.
- W2173474966 crossrefType "journal-article" @default.
- W2173474966 hasAuthorship W2173474966A5000588962 @default.
- W2173474966 hasAuthorship W2173474966A5050276095 @default.
- W2173474966 hasAuthorship W2173474966A5060606530 @default.
- W2173474966 hasAuthorship W2173474966A5061390674 @default.
- W2173474966 hasAuthorship W2173474966A5070744352 @default.
- W2173474966 hasConcept C104317684 @default.
- W2173474966 hasConcept C134459356 @default.
- W2173474966 hasConcept C134935766 @default.
- W2173474966 hasConcept C143425029 @default.
- W2173474966 hasConcept C167227067 @default.
- W2173474966 hasConcept C25602115 @default.
- W2173474966 hasConcept C2777658100 @default.
- W2173474966 hasConcept C37846818 @default.
- W2173474966 hasConcept C502942594 @default.
- W2173474966 hasConcept C54355233 @default.
- W2173474966 hasConcept C552990157 @default.
- W2173474966 hasConcept C64927066 @default.
- W2173474966 hasConcept C83640560 @default.
- W2173474966 hasConcept C86803240 @default.
- W2173474966 hasConcept C95444343 @default.
- W2173474966 hasConceptScore W2173474966C104317684 @default.
- W2173474966 hasConceptScore W2173474966C134459356 @default.
- W2173474966 hasConceptScore W2173474966C134935766 @default.
- W2173474966 hasConceptScore W2173474966C143425029 @default.
- W2173474966 hasConceptScore W2173474966C167227067 @default.
- W2173474966 hasConceptScore W2173474966C25602115 @default.
- W2173474966 hasConceptScore W2173474966C2777658100 @default.
- W2173474966 hasConceptScore W2173474966C37846818 @default.
- W2173474966 hasConceptScore W2173474966C502942594 @default.
- W2173474966 hasConceptScore W2173474966C54355233 @default.
- W2173474966 hasConceptScore W2173474966C552990157 @default.
- W2173474966 hasConceptScore W2173474966C64927066 @default.
- W2173474966 hasConceptScore W2173474966C83640560 @default.
- W2173474966 hasConceptScore W2173474966C86803240 @default.
- W2173474966 hasConceptScore W2173474966C95444343 @default.
- W2173474966 hasIssue "2" @default.
- W2173474966 hasLocation W21734749661 @default.
- W2173474966 hasLocation W21734749662 @default.
- W2173474966 hasOpenAccess W2173474966 @default.
- W2173474966 hasPrimaryLocation W21734749661 @default.
- W2173474966 hasRelatedWork W1546354556 @default.
- W2173474966 hasRelatedWork W1979540894 @default.
- W2173474966 hasRelatedWork W1991397664 @default.
- W2173474966 hasRelatedWork W2002421203 @default.
- W2173474966 hasRelatedWork W2064005586 @default.
- W2173474966 hasRelatedWork W2128255364 @default.
- W2173474966 hasRelatedWork W2564863220 @default.
- W2173474966 hasRelatedWork W2811264472 @default.
- W2173474966 hasRelatedWork W2897716354 @default.
- W2173474966 hasRelatedWork W4229019610 @default.
- W2173474966 hasVolume "16" @default.
- W2173474966 isParatext "false" @default.
- W2173474966 isRetracted "false" @default.
- W2173474966 magId "2173474966" @default.
- W2173474966 workType "article" @default.