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• W2173535683 abstract "The unsymmetrical nicotinamide-N-oxide moiety in compound 1 was replaced with symmetrical isonicotinamides as well as 4,6-dimethyl pyrimidine-5-carboxamides. Compound 16 from the latter set reduced the number of rotamers, improved potency of inhibiting UIV entry, slightly diminished the affinity for the muscarine receptors and showed very good oral absorption." @default.
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• W2173535683 date "2003-02-01" @default.
• W2173535683 modified "2023-10-13" @default.
• W2173535683 title "Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides" @default.
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• W2173535683 doi "https://doi.org/10.1016/s0960-894x(02)00918-6" @default.
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