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- W2173596377 abstract "follow-up time from first biologic 4.5 years (IQR 1.4-7.6). 1751 IFX infusions were given, with increasing frequency over time reflecting the shift from episodic to maintenance therapy. Infusion number increased by 202.6% between 2004-5 and 143 patients commenced maintenance anti-TNF from 2005-11, in contrast with only 14 up to 2005. Median time from diagnosis to first anti-TNF was 97 months up to 2005, falling to 52 months from 200611. Of 72 CD patients treated with ADA, 37 required dose escalation to weekly, at a median interval of 6 months (median 29.5 months follow-up). No anti-TNF naive patients required dose escalation, but 12/18 patients starting ADA due to secondary loss of response to IFX required weekly therapy (66.7%). There were 238 hospital admissions (93 for disease flares) in the year preceding anti-TNF therapy, falling to 197 admissions (35 for disease flares) in the year after treatment initiation. Faecal calprotectin (FC) before and 3 months after starting anti-TNF was available for 22 patients; this fell by a median of 470.5 mcg/g. 39 infusion reactions were observed in 35 IFX-treated patients; 6 followed a treatment break of 1471568 days. 8 serum sickness-like reactions were observed following IFX, and 2 with ADA. Conclusion: Outcome of changes in treatment patterns will inform unanswered questions regarding patient selection and length of therapy. Drug holiday from IFX remains an indication for ADA. Innovations in monitoring response to anti-TNF therapy, notably recording of HBI and FC before every treatment (initiated in our centre during 2011) will further aid decision-making." @default.
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- W2173596377 date "2012-05-01" @default.
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- W2173596377 title "Tu1252 Effect of Budesonide MMx 6 mg on the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Patients With Ulcerative Colitis: Results From a Phase III, 12 Month Safety and Extended use Study" @default.
- W2173596377 doi "https://doi.org/10.1016/s0016-5085(12)63046-7" @default.
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