FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173672722> ?p ?o ?g. }

• W2173672722 endingPage "1841" @default.
• W2173672722 startingPage "1829" @default.
• W2173672722 abstract "OBJECT The authors of this study used a newly developed intracranial optical fiber device to deliver near-infrared light (NIr) to the midbrain of 6-hydroxydopamine (6-OHDA)-lesioned rats, a model of Parkinson's disease. The authors explored whether NIr had any impact on apomorphine-induced turning behavior and whether it was neuroprotective. METHODS Two NIr powers (333 nW and 0.16 mW), modes of delivery (pulse and continuous), and total doses (634 mJ and 304 J) were tested, together with the feasibility of a midbrain implant site, one considered for later use in primates. Following a striatal 6-OHDA injection, the NIr optical fiber device was implanted surgically into the midline midbrain area of Wistar rats. Animals were tested for apomorphine-induced rotations, and then, 23 days later, their brains were aldehyde fixed for routine immunohistochemical analysis. RESULTS The results showed that there was no evidence of tissue toxicity by NIr in the midbrain. After 6-OHDA lesion, regardless of mode of delivery or total dose, NIr reduced apomorphine-induced rotations at the stronger, but not at the weaker, power. The authors found that neuroprotection, as assessed by tyrosine hydroxylase expression in midbrain dopaminergic cells, could account for some, but not all, of the observed behavioral improvements; the groups that were associated with fewer rotations did not all necessarily have a greater number of surviving cells. There may have been other symptomatic elements contributing to behavioral improvements in these rats. CONCLUSIONS In summary, when delivered at the appropriate power, delivery mode, and dosage, NIr treatment provided both improved behavior and neuroprotection in 6-OHDA-lesioned rats." @default.
• W2173672722 created "2016-06-24" @default.
• W2173672722 creator A5013514286 @default.
• W2173672722 creator A5018241269 @default.
• W2173672722 creator A5018688335 @default.
• W2173672722 creator A5036386407 @default.
• W2173672722 creator A5058049572 @default.
• W2173672722 creator A5059060775 @default.
• W2173672722 creator A5068301249 @default.
• W2173672722 creator A5070087383 @default.
• W2173672722 creator A5070565427 @default.
• W2173672722 creator A5074299818 @default.
• W2173672722 creator A5084603865 @default.
• W2173672722 creator A5089058559 @default.
• W2173672722 date "2016-06-01" @default.
• W2173672722 modified "2023-10-18" @default.
• W2173672722 title "Intracranial application of near-infrared light in a hemi-parkinsonian rat model: the impact on behavior and cell survival" @default.
• W2173672722 cites W142254453 @default.
• W2173672722 cites W1562903965 @default.
• W2173672722 cites W1955564757 @default.
• W2173672722 cites W1965796163 @default.
• W2173672722 cites W1972239396 @default.
• W2173672722 cites W1978025210 @default.
• W2173672722 cites W1982189761 @default.
• W2173672722 cites W1983427888 @default.
• W2173672722 cites W2007130566 @default.
• W2173672722 cites W2009041796 @default.
• W2173672722 cites W2023505596 @default.
• W2173672722 cites W2023838096 @default.
• W2173672722 cites W2024906181 @default.
• W2173672722 cites W2027094797 @default.
• W2173672722 cites W2027274005 @default.
• W2173672722 cites W2030536065 @default.
• W2173672722 cites W2031310027 @default.
• W2173672722 cites W2031968135 @default.
• W2173672722 cites W2039197913 @default.
• W2173672722 cites W2046632451 @default.
• W2173672722 cites W2059272828 @default.
• W2173672722 cites W2063194492 @default.
• W2173672722 cites W2066058707 @default.
• W2173672722 cites W2071669902 @default.
• W2173672722 cites W2073384627 @default.
• W2173672722 cites W2074432223 @default.
• W2173672722 cites W2085960334 @default.
• W2173672722 cites W2087068236 @default.
• W2173672722 cites W2088155076 @default.
• W2173672722 cites W2088318694 @default.
• W2173672722 cites W2088364564 @default.
• W2173672722 cites W2093440585 @default.
• W2173672722 cites W2093799182 @default.
• W2173672722 cites W2099811944 @default.
• W2173672722 cites W2110065186 @default.
• W2173672722 cites W2110789971 @default.
• W2173672722 cites W2132672239 @default.
• W2173672722 cites W2135118056 @default.
• W2173672722 cites W2135659582 @default.
• W2173672722 cites W2143380336 @default.
• W2173672722 cites W2145954079 @default.
• W2173672722 cites W2156756890 @default.
• W2173672722 cites W2157583512 @default.
• W2173672722 cites W2158989056 @default.
• W2173672722 doi "https://doi.org/10.3171/2015.5.jns15735" @default.
• W2173672722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26613166" @default.
• W2173672722 hasPublicationYear "2016" @default.
• W2173672722 type Work @default.
• W2173672722 sameAs 2173672722 @default.
• W2173672722 citedByCount "30" @default.
• W2173672722 countsByYear W21736727222016 @default.
• W2173672722 countsByYear W21736727222017 @default.
• W2173672722 countsByYear W21736727222018 @default.
• W2173672722 countsByYear W21736727222019 @default.
• W2173672722 countsByYear W21736727222020 @default.
• W2173672722 countsByYear W21736727222021 @default.
• W2173672722 countsByYear W21736727222022 @default.
• W2173672722 countsByYear W21736727222023 @default.
• W2173672722 crossrefType "journal-article" @default.
• W2173672722 hasAuthorship W2173672722A5013514286 @default.
• W2173672722 hasAuthorship W2173672722A5018241269 @default.
• W2173672722 hasAuthorship W2173672722A5018688335 @default.
• W2173672722 hasAuthorship W2173672722A5036386407 @default.
• W2173672722 hasAuthorship W2173672722A5058049572 @default.
• W2173672722 hasAuthorship W2173672722A5059060775 @default.
• W2173672722 hasAuthorship W2173672722A5068301249 @default.
• W2173672722 hasAuthorship W2173672722A5070087383 @default.
• W2173672722 hasAuthorship W2173672722A5070565427 @default.
• W2173672722 hasAuthorship W2173672722A5074299818 @default.
• W2173672722 hasAuthorship W2173672722A5084603865 @default.
• W2173672722 hasAuthorship W2173672722A5089058559 @default.
• W2173672722 hasBestOaLocation W21736727221 @default.
• W2173672722 hasConcept C126322002 @default.
• W2173672722 hasConcept C137183658 @default.
• W2173672722 hasConcept C142724271 @default.
• W2173672722 hasConcept C159167319 @default.
• W2173672722 hasConcept C169760540 @default.
• W2173672722 hasConcept C204232928 @default.
• W2173672722 hasConcept C25498285 @default.
• W2173672722 hasConcept C2777525119 @default.
• W2173672722 hasConcept C2780938664 @default.

• next