Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173673275> ?p ?o ?g. }
- W2173673275 endingPage "259" @default.
- W2173673275 startingPage "243" @default.
- W2173673275 abstract "Adult mouse ultrasonic vocalizations (USVs) occur in multiple behavioral and stimulus contexts associated with various levels of arousal, emotion and social interaction. Here, in three experiments of increasing stimulus intensity (water; female urine; male interacting with adult female), we tested the hypothesis that USVs of adult males express the strength of arousal and emotion via different USV parameters (18 parameters analyzed). Furthermore, we analyzed two mouse lines with heterozygous Foxp2 mutations (R552H missense, S321X nonsense), known to produce severe speech and language disorders in humans. These experiments allowed us to test whether intact Foxp2 function is necessary for developing full adult USV repertoires, and whether mutations of this gene influence instinctive vocal expressions based on arousal and emotion. The results suggest that USV calling rate characterizes the arousal level, while sound pressure and spectrotemporal call complexity (overtones/harmonics, type of frequency jumps) may provide indices of levels of positive emotion. The presence of Foxp2 mutations did not qualitatively affect the USVs; all USV types that were found in wild-type animals also occurred in heterozygous mutants. However, mice with Foxp2 mutations displayed quantitative differences in USVs as compared to wild-types, and these changes were context dependent. Compared to wild-type animals, heterozygous mutants emitted mainly longer and louder USVs at higher minimum frequencies with a higher occurrence rate of overtones/harmonics and complex frequency jump types. We discuss possible hypotheses about Foxp2 influence on emotional vocal expressions, which can be investigated in future experiments using selective knockdown of Foxp2 in specific brain circuits." @default.
- W2173673275 created "2016-06-24" @default.
- W2173673275 creator A5032266999 @default.
- W2173673275 creator A5033027778 @default.
- W2173673275 creator A5081882177 @default.
- W2173673275 date "2016-01-13" @default.
- W2173673275 modified "2023-10-15" @default.
- W2173673275 title "Ultrasonic vocalizations of adult male<i>Foxp2</i>-mutant mice: behavioral contexts of arousal and emotion" @default.
- W2173673275 cites W1488156371 @default.
- W2173673275 cites W1886006583 @default.
- W2173673275 cites W1963818866 @default.
- W2173673275 cites W1964973030 @default.
- W2173673275 cites W1965763723 @default.
- W2173673275 cites W1966014364 @default.
- W2173673275 cites W1972137367 @default.
- W2173673275 cites W1975396695 @default.
- W2173673275 cites W1975949746 @default.
- W2173673275 cites W1976862716 @default.
- W2173673275 cites W1978912730 @default.
- W2173673275 cites W1981147791 @default.
- W2173673275 cites W1986382714 @default.
- W2173673275 cites W1991053998 @default.
- W2173673275 cites W1991269326 @default.
- W2173673275 cites W1995431490 @default.
- W2173673275 cites W1999247495 @default.
- W2173673275 cites W1999928356 @default.
- W2173673275 cites W2000054444 @default.
- W2173673275 cites W2002510254 @default.
- W2173673275 cites W2002859524 @default.
- W2173673275 cites W2003392454 @default.
- W2173673275 cites W2003863298 @default.
- W2173673275 cites W2004187422 @default.
- W2173673275 cites W2005430804 @default.
- W2173673275 cites W2005885879 @default.
- W2173673275 cites W2008275949 @default.
- W2173673275 cites W2012376770 @default.
- W2173673275 cites W2013545920 @default.
- W2173673275 cites W2013560061 @default.
- W2173673275 cites W2017321032 @default.
- W2173673275 cites W2018047552 @default.
- W2173673275 cites W2018338387 @default.
- W2173673275 cites W2021485892 @default.
- W2173673275 cites W2022434602 @default.
- W2173673275 cites W2028310558 @default.
- W2173673275 cites W2032196030 @default.
- W2173673275 cites W2033218779 @default.
- W2173673275 cites W2033342861 @default.
- W2173673275 cites W2034696724 @default.
- W2173673275 cites W2039098837 @default.
- W2173673275 cites W2040007053 @default.
- W2173673275 cites W2040886375 @default.
- W2173673275 cites W2045733845 @default.
- W2173673275 cites W2047262027 @default.
- W2173673275 cites W2049699287 @default.
- W2173673275 cites W2049953148 @default.
- W2173673275 cites W2051124777 @default.
- W2173673275 cites W2056366493 @default.
- W2173673275 cites W2056439165 @default.
- W2173673275 cites W2057329083 @default.
- W2173673275 cites W2057874135 @default.
- W2173673275 cites W2062496408 @default.
- W2173673275 cites W2072206615 @default.
- W2173673275 cites W2074998842 @default.
- W2173673275 cites W2077842744 @default.
- W2173673275 cites W2082658691 @default.
- W2173673275 cites W2083433785 @default.
- W2173673275 cites W2090165657 @default.
- W2173673275 cites W2100720445 @default.
- W2173673275 cites W2101506937 @default.
- W2173673275 cites W2104636749 @default.
- W2173673275 cites W2106524861 @default.
- W2173673275 cites W2109603175 @default.
- W2173673275 cites W2112903741 @default.
- W2173673275 cites W2117693696 @default.
- W2173673275 cites W2120716183 @default.
- W2173673275 cites W2131915909 @default.
- W2173673275 cites W2133392227 @default.
- W2173673275 cites W2135372066 @default.
- W2173673275 cites W2135394513 @default.
- W2173673275 cites W2137801136 @default.
- W2173673275 cites W2137955727 @default.
- W2173673275 cites W2149628368 @default.
- W2173673275 cites W2152860360 @default.
- W2173673275 cites W2155001207 @default.
- W2173673275 cites W2164771787 @default.
- W2173673275 cites W2165225096 @default.
- W2173673275 cites W2169944034 @default.
- W2173673275 cites W2328056838 @default.
- W2173673275 cites W2490758920 @default.
- W2173673275 cites W28828025 @default.
- W2173673275 cites W4252200890 @default.
- W2173673275 doi "https://doi.org/10.1111/gbb.12274" @default.
- W2173673275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26566793" @default.
- W2173673275 hasPublicationYear "2016" @default.
- W2173673275 type Work @default.
- W2173673275 sameAs 2173673275 @default.
- W2173673275 citedByCount "43" @default.
- W2173673275 countsByYear W21736732752016 @default.