FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173718005> ?p ?o ?g. }

• W2173718005 endingPage "52" @default.
• W2173718005 startingPage "944" @default.
• W2173718005 abstract "A variety of sexually transmitted diseases frequently accompany infection with human papillomavirus and stimulate inflammation of the cervical mucosa. Inflammation and cell injury cause release of proinflammatory cytokines, which in turn might regulate growth of human papillomavirus-infected cells. This study compared the interaction of the proinflammatory cytokine, interleukin-6 (IL-6), and its soluble receptor with normal ecto- and endocervical cells, human papillomavirus-immortalized ectocervical cells, and squamous carcinoma-derived cell lines. Proliferation of normal cervical cells was enhanced by IL-6 but inhibited by its soluble receptor. However, both IL-6 and its soluble receptor significantly stimulated growth of the three immortal and four cervical carcinoma-derived cell lines analyzed. Stimulation by IL-6 was dose dependent and was blocked by an antibody that neutralized IL-6 activity. IL-6-mediated proliferation was accompanied by increased expression of RNAs encoding transforming growth factor-alpha and amphiregulin, two epidermal growth factor receptor ligands. Furthermore, growth stimulation by IL-6 was significantly inhibited by antibodies that either blocked signal transduction by the epidermal growth factor receptor or that neutralized transforming growth factor-alpha or amphiregulin activity. Thus, IL-6 stimulates proliferation of human papillomavirus-immortalized cervical cells via an epidermal growth factor receptor-dependent pathway involving autocrine stimulation by transforming growth factor-alpha and amphiregulin." @default.
• W2173718005 created "2016-06-24" @default.
• W2173718005 creator A5015360027 @default.
• W2173718005 creator A5074676696 @default.
• W2173718005 creator A5079026310 @default.
• W2173718005 date "1995-04-01" @default.
• W2173718005 modified "2023-09-23" @default.
• W2173718005 title "Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro." @default.
• W2173718005 cites W135877420 @default.
• W2173718005 cites W1510936315 @default.
• W2173718005 cites W1535632992 @default.
• W2173718005 cites W1536718388 @default.
• W2173718005 cites W1623235930 @default.
• W2173718005 cites W1756723285 @default.
• W2173718005 cites W1879225571 @default.
• W2173718005 cites W1924000143 @default.
• W2173718005 cites W1973557583 @default.
• W2173718005 cites W1981194583 @default.
• W2173718005 cites W1988358428 @default.
• W2173718005 cites W1989001888 @default.
• W2173718005 cites W1995646479 @default.
• W2173718005 cites W1998255684 @default.
• W2173718005 cites W2002076761 @default.
• W2173718005 cites W2015376103 @default.
• W2173718005 cites W2017607160 @default.
• W2173718005 cites W2018920600 @default.
• W2173718005 cites W2034296167 @default.
• W2173718005 cites W2046041844 @default.
• W2173718005 cites W2046396043 @default.
• W2173718005 cites W2046756969 @default.
• W2173718005 cites W2054012934 @default.
• W2173718005 cites W2058554371 @default.
• W2173718005 cites W2062685912 @default.
• W2173718005 cites W2073345009 @default.
• W2173718005 cites W2073402472 @default.
• W2173718005 cites W2092619681 @default.
• W2173718005 cites W2097685385 @default.
• W2173718005 cites W2120486924 @default.
• W2173718005 cites W2124806986 @default.
• W2173718005 cites W2125555128 @default.
• W2173718005 cites W2155958456 @default.
• W2173718005 cites W2158946057 @default.
• W2173718005 cites W2289970674 @default.
• W2173718005 cites W2337028134 @default.
• W2173718005 cites W2414612509 @default.
• W2173718005 cites W3022691628 @default.
• W2173718005 cites W55000995 @default.
• W2173718005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1869260" @default.
• W2173718005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7717461" @default.
• W2173718005 hasPublicationYear "1995" @default.
• W2173718005 type Work @default.
• W2173718005 sameAs 2173718005 @default.
• W2173718005 citedByCount "28" @default.
• W2173718005 countsByYear W21737180052012 @default.
• W2173718005 countsByYear W21737180052013 @default.
• W2173718005 countsByYear W21737180052014 @default.
• W2173718005 countsByYear W21737180052015 @default.
• W2173718005 countsByYear W21737180052018 @default.
• W2173718005 countsByYear W21737180052022 @default.
• W2173718005 crossrefType "journal-article" @default.
• W2173718005 hasAuthorship W2173718005A5015360027 @default.
• W2173718005 hasAuthorship W2173718005A5074676696 @default.
• W2173718005 hasAuthorship W2173718005A5079026310 @default.
• W2173718005 hasConcept C118131993 @default.
• W2173718005 hasConcept C125555471 @default.
• W2173718005 hasConcept C126322002 @default.
• W2173718005 hasConcept C128240485 @default.
• W2173718005 hasConcept C134018914 @default.
• W2173718005 hasConcept C164027704 @default.
• W2173718005 hasConcept C170493617 @default.
• W2173718005 hasConcept C203014093 @default.
• W2173718005 hasConcept C26375932 @default.
• W2173718005 hasConcept C2775960820 @default.
• W2173718005 hasConcept C2776362946 @default.
• W2173718005 hasConcept C2776914184 @default.
• W2173718005 hasConcept C2778690821 @default.
• W2173718005 hasConcept C2779438470 @default.
• W2173718005 hasConcept C2780806702 @default.
• W2173718005 hasConcept C502942594 @default.
• W2173718005 hasConcept C54355233 @default.
• W2173718005 hasConcept C55493867 @default.
• W2173718005 hasConcept C62112901 @default.
• W2173718005 hasConcept C62478195 @default.
• W2173718005 hasConcept C71924100 @default.
• W2173718005 hasConcept C86803240 @default.
• W2173718005 hasConcept C95444343 @default.
• W2173718005 hasConceptScore W2173718005C118131993 @default.
• W2173718005 hasConceptScore W2173718005C125555471 @default.
• W2173718005 hasConceptScore W2173718005C126322002 @default.
• W2173718005 hasConceptScore W2173718005C128240485 @default.
• W2173718005 hasConceptScore W2173718005C134018914 @default.
• W2173718005 hasConceptScore W2173718005C164027704 @default.
• W2173718005 hasConceptScore W2173718005C170493617 @default.
• W2173718005 hasConceptScore W2173718005C203014093 @default.
• W2173718005 hasConceptScore W2173718005C26375932 @default.
• W2173718005 hasConceptScore W2173718005C2775960820 @default.
• W2173718005 hasConceptScore W2173718005C2776362946 @default.
• W2173718005 hasConceptScore W2173718005C2776914184 @default.

• next