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• W2173755462 abstract "The sub-renal capsule graft site for in vivo growth and development of developing organs can be used to great advantage in the rescue of organ rudiments from embryonic or birth lethal mutant mice, which permits examination of the full impact of gene knockout in all phases of development from morphogenesis to adult functional differentiation. Another use of the sub-renal capsule graft site is the examination of normal and chemically perturbed development of human fetal organs. Tissue recombinants composed of various types of epithelium and mesenchyme, when grafted under the renal capsule undergo normal development and in 3-4 weeks achieve full adult functional cytodifferentiation. The investigator can control many of the developmental parameters of the graft such as endocrine status of the host and treatment of the host with a variety of biologically active agents to assess their effects on development and differentiation." @default.
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• W2173755462 date "2016-04-01" @default.
• W2173755462 modified "2023-09-25" @default.
• W2173755462 title "Use of sub-renal capsule transplantation in developmental biology" @default.
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• W2173755462 doi "https://doi.org/10.1016/j.diff.2015.10.007" @default.
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