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- W2173760983 abstract "The increasing use of Chinese herbal medicines (CHMs) as complementary therapy and dietary supplement has been greatly raising the concerns about potential herb–drug interactions (HDIs). HDIs may cause the augmented or antagonized effects of prescription drugs, resulting in unexpected clinical outcomes. Therefore, it is of significance to identify or predict potential HDIs, and to delineate the underlying mechanisms. Drug transporters play key roles in transmembrane passage of a large number of drugs, affecting their absorption, distribution and elimination. Modulation of drug transporters has been recognized as one of the main causes of HDIs. In the last decade, a growing number of Chinese medicinal herbs and their derived phytochemicals have been identified to have modulatory effect toward transporter proteins, leading to pharmacokinetic HDIs when concomitantly used with conventional drugs. Some of these transporter-mediated interactions have already shown clinical significance. This review article focuses on two major transporter superfamilies, the solute carrier (SLC) and the ATP-binding cassette (ABC) transporters, to provide the recent advanced knowledge on CHMs and their inherent phytochemicals that interact with these transporters, and their induced pharmacokinetic HDIs from both preclinical and clinical aspects. In addition, the challenges and strategy for studying HDIs are also discussed." @default.
- W2173760983 created "2016-06-24" @default.
- W2173760983 creator A5047540439 @default.
- W2173760983 creator A5048341648 @default.
- W2173760983 creator A5052863980 @default.
- W2173760983 creator A5065643069 @default.
- W2173760983 date "2016-07-01" @default.
- W2173760983 modified "2023-09-27" @default.
- W2173760983 title "Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb–drug interactions" @default.
- W2173760983 cites W1504733165 @default.
- W2173760983 cites W1518312411 @default.
- W2173760983 cites W1532102126 @default.
- W2173760983 cites W1539293547 @default.
- W2173760983 cites W1550259003 @default.
- W2173760983 cites W1559010782 @default.
- W2173760983 cites W1566015146 @default.
- W2173760983 cites W1571571100 @default.
- W2173760983 cites W1601512098 @default.
- W2173760983 cites W1791753707 @default.
- W2173760983 cites W1963779461 @default.
- W2173760983 cites W1965981994 @default.
- W2173760983 cites W1966271190 @default.
- W2173760983 cites W1967077419 @default.
- W2173760983 cites W1967735525 @default.
- W2173760983 cites W1968966910 @default.
- W2173760983 cites W1969067003 @default.
- W2173760983 cites W1969752754 @default.
- W2173760983 cites W1970199287 @default.
- W2173760983 cites W1971578783 @default.
- W2173760983 cites W1972514592 @default.
- W2173760983 cites W1975693150 @default.
- W2173760983 cites W1978423233 @default.
- W2173760983 cites W1981178961 @default.
- W2173760983 cites W1982420531 @default.
- W2173760983 cites W1983389988 @default.
- W2173760983 cites W1983594708 @default.
- W2173760983 cites W1983979866 @default.
- W2173760983 cites W1985420819 @default.
- W2173760983 cites W1986588112 @default.
- W2173760983 cites W1987595974 @default.
- W2173760983 cites W1991264125 @default.
- W2173760983 cites W1991327193 @default.
- W2173760983 cites W1991826964 @default.
- W2173760983 cites W1991904087 @default.
- W2173760983 cites W1993892607 @default.
- W2173760983 cites W1993954798 @default.
- W2173760983 cites W1994585405 @default.
- W2173760983 cites W1996386764 @default.
- W2173760983 cites W1996607198 @default.
- W2173760983 cites W1997314073 @default.
- W2173760983 cites W1997947304 @default.
- W2173760983 cites W2001318612 @default.
- W2173760983 cites W2001737389 @default.
- W2173760983 cites W2002867712 @default.
- W2173760983 cites W2003366674 @default.
- W2173760983 cites W2005087304 @default.
- W2173760983 cites W2005770166 @default.
- W2173760983 cites W2006424792 @default.
- W2173760983 cites W2007484825 @default.
- W2173760983 cites W2007752971 @default.
- W2173760983 cites W2009143405 @default.
- W2173760983 cites W2009903606 @default.
- W2173760983 cites W2013020516 @default.
- W2173760983 cites W2014580059 @default.
- W2173760983 cites W2014910789 @default.
- W2173760983 cites W2015154953 @default.
- W2173760983 cites W2018822594 @default.
- W2173760983 cites W2019243955 @default.
- W2173760983 cites W2021202160 @default.
- W2173760983 cites W2023513068 @default.
- W2173760983 cites W2025505089 @default.
- W2173760983 cites W2026045480 @default.
- W2173760983 cites W2026873000 @default.
- W2173760983 cites W2028933151 @default.
- W2173760983 cites W2030691662 @default.
- W2173760983 cites W2030851296 @default.
- W2173760983 cites W2031866272 @default.
- W2173760983 cites W2033493930 @default.
- W2173760983 cites W2035339419 @default.
- W2173760983 cites W2035340874 @default.
- W2173760983 cites W2035913987 @default.
- W2173760983 cites W2037705821 @default.
- W2173760983 cites W2038961046 @default.
- W2173760983 cites W2041813321 @default.
- W2173760983 cites W2043493115 @default.
- W2173760983 cites W2044154925 @default.
- W2173760983 cites W2044439690 @default.
- W2173760983 cites W2045567622 @default.
- W2173760983 cites W2045922658 @default.
- W2173760983 cites W2046168100 @default.
- W2173760983 cites W2046979250 @default.
- W2173760983 cites W2047668061 @default.
- W2173760983 cites W2047705797 @default.
- W2173760983 cites W2048447345 @default.
- W2173760983 cites W2049328486 @default.
- W2173760983 cites W2049413706 @default.
- W2173760983 cites W2050011032 @default.
- W2173760983 cites W2051192995 @default.