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- W217382042 endingPage "270" @default.
- W217382042 startingPage "237" @default.
- W217382042 abstract "This chapter describes the reactions of the thiyl radical together with the ways in which this species may be generated and the structural features that govern its rate of formation. The possible mechanisms by which one-electron oxidation of thiols leads to both beneficial and harmful effects in living systems are discussed. The major pathway for decay of the thiyl radical under physiological conditions involves formation of the corresponding disulfide with concomitant production of “active oxygen” species; there is evidence that the latter are responsible for many of the toxic effects associated with one-electron oxidation of thiols. One-electron oxidation of thiols can be mediated in many ways. One of the most important routes involves reaction with molecular oxygen, catalyzed by transition metals. Although much has been achieved with regard to understanding the consequences of one-electron oxidation of both endogenous and xenobiotic thiols, much remains to be done. In particular, a fuller understanding of the delicate balance that exists between the pro- and the anti-oxidant activities of these compounds would be valuable, not only in determining mechanisms of toxicity and protection but also in the design of cytotoxic drugs for therapeutic purposes." @default.
- W217382042 created "2016-06-24" @default.
- W217382042 creator A5008821697 @default.
- W217382042 date "1994-01-01" @default.
- W217382042 modified "2023-10-13" @default.
- W217382042 title "Bioactivation of Thiols by One-Electron Oxidation" @default.
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