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- W2173910169 endingPage "669" @default.
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- W2173910169 abstract "Much work in drug metabolism lends itself to in vitro and in vivo correlations, with the ultimate aim of applying data obtained from a much simplified in vitro system to predict events in vivo (1-4). Investigators have long recog nized that the rates of metabolite formation in vitro, whether examined in a reconstituted system of purified enzy· me, tissue homogenate, subcellular frac tion, or intact isolated cells, are governed by the kinetic constants V max and Km for the underlying enzymes involved, and by the availability of the substrate or cosubstrate. However, the incubation conditions usually include high substrate and cosubstrate concentrations such that the enzyme becomes rate-limiting in the overall reaction." @default.
- W2173910169 created "2016-06-24" @default.
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- W2173910169 creator A5077009004 @default.
- W2173910169 date "1992-04-01" @default.
- W2173910169 modified "2023-10-18" @default.
- W2173910169 title "Determinants of Metabolite Disposition" @default.
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- W2173910169 doi "https://doi.org/10.1146/annurev.pa.32.040192.003203" @default.
- W2173910169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1605580" @default.
- W2173910169 hasPublicationYear "1992" @default.
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