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- W2173959722 abstract "Studies were carried out using instrumented unanesthetized rats to determine the long-term effects of arginine vasopressin (AVP) and a specific vasopressin V 1 receptor agonist (V 1 AG; [Phe 2 , Ile 3 , Orn 8 ]- vasopressin) on the renal medullary blood flow and arterial blood pressure. It was hypothesized that the hypertension observed with chronic medullary infusion of a V 1 receptor agonist may be associated with a sustained reduction of blood flow, whereas infusion of AVP may fail to produce a sustained reduction of blood flow and thereby be unable to produce hypertension. Uninephrectomized Sprague-Dawley rats were prepared with implanted renal cortical and medullary optical fibers for daily measurements of cortical and medullary blood flow using laser-Doppler flowmetry techniques. An implanted renal medullary interstitial infusion catheter delivered either AVP or a specific V 1 AG at a dose of 2 ng ⋅ kg −1 ⋅ min −1 over a period of 5 days. The V 1 AG produced no change of cortical blood flow but a chronic 35% reduction of medullary blood flow ( P < 0.05) and mild hypertension (11 ± 4 mmHg, P < 0.05). AVP produced only an initial, nonsignificant 1- to 2-day reduction of medullary blood flow (−13%) and failed to raise arterial pressure significantly. We conclude that a sustained V 1 AG response is necessary to achieve a chronic reduction of medullary blood flow and hypertension. The present data are consistent with the idea that chronic stimulation of V 2 receptors by AVP offsets the vasoconstrictor and hypertension actions of AVP-induced stimulation of medullary V 1 receptors." @default.
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- W2173959722 date "1998-11-01" @default.
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- W2173959722 title "Effects of long-term vasopressin receptor stimulation on medullary blood flow and arterial pressure" @default.
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- W2173959722 doi "https://doi.org/10.1152/ajpregu.1998.275.5.r1420" @default.
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