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• W2173983331 abstract "We found that putative metabolites of docosahexaenoic acid (DHA) are strong PPARgamma activators and potential antidiabetic agents. We designed DHA derivatives based on the crystal structure of PPARgamma, synthesized them and evaluated their activities in vitro and in vivo. The efficacy of 5E-4-hydroxy-DHA 2a as a PPARgamma activator was about fourfold stronger than that of pioglitazone. Furthermore, the 4-keto derivative (10b) showed antidiabetic activity in animal models without producing undesirable effects such as obesity and hepatotoxicity." @default.
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• W2173983331 date "2005-02-01" @default.
• W2173983331 modified "2023-10-16" @default.
• W2173983331 title "Identification of putative metabolites of docosahexaenoic acid as potent PPARγ agonists and antidiabetic agents" @default.
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• W2173983331 doi "https://doi.org/10.1016/j.bmcl.2004.11.053" @default.
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