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- W2173990921 abstract "The apolipoprotein E (APOE) ϵ4 allele is known to be a major genetic risk factor for Alzheimer's disease (AD). It has been linked to especially episodic memory decline and hippocampal atrophy in both healthy and demented elderly populations. In young adults, ϵ4 carriers have shown better performance in episodic memory compared to non-carriers. Spatial memory, however, has not been thoroughly assessed in relation to APOE in spite of its dependence on the hippocampus. In this study, we assessed the effect of APOE genotype on a variety of spatial and episodic memory tasks as well as hippocampal volume assessed through manual tracing in a sample of young adults (N=123). We also assessed whether potential effects were modulated by sex. The presence of one or more ϵ4 alleles had positive effects on spatial function and memory and object location memory, but no effect on word recognition. Men were superior to women in spatial function and memory but there were no sex differences in the other tasks. In spite of APOE ϵ4 carriers having superior performance in several memory tasks, no difference was found as a function of APOE genotype in hippocampal volume. To our knowledge, this study is the first to show that APOE ϵ4 has a positive effect on spatial ability in young adults." @default.
- W2173990921 created "2016-06-24" @default.
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- W2173990921 date "2016-02-01" @default.
- W2173990921 modified "2023-10-02" @default.
- W2173990921 title "Apolipoprotein E ϵ4 is positively related to spatial performance but unrelated to hippocampal volume in healthy young adults" @default.
- W2173990921 cites W1506252725 @default.
- W2173990921 cites W1536877609 @default.
- W2173990921 cites W1580593957 @default.
- W2173990921 cites W1681464763 @default.
- W2173990921 cites W1956968755 @default.
- W2173990921 cites W1967977072 @default.
- W2173990921 cites W1970591030 @default.
- W2173990921 cites W1970792572 @default.
- W2173990921 cites W1976879698 @default.
- W2173990921 cites W1977551077 @default.
- W2173990921 cites W1983182638 @default.
- W2173990921 cites W1984737558 @default.
- W2173990921 cites W1984997727 @default.
- W2173990921 cites W1989497180 @default.
- W2173990921 cites W1999260032 @default.
- W2173990921 cites W2000555003 @default.
- W2173990921 cites W2005574634 @default.
- W2173990921 cites W2008491286 @default.
- W2173990921 cites W2009339691 @default.
- W2173990921 cites W2017169966 @default.
- W2173990921 cites W2021709476 @default.
- W2173990921 cites W2022515909 @default.
- W2173990921 cites W2031951838 @default.
- W2173990921 cites W2034040074 @default.
- W2173990921 cites W2034968148 @default.
- W2173990921 cites W2035236207 @default.
- W2173990921 cites W2036362108 @default.
- W2173990921 cites W2036404017 @default.
- W2173990921 cites W2037354720 @default.
- W2173990921 cites W2038418010 @default.
- W2173990921 cites W2041325253 @default.
- W2173990921 cites W2043084329 @default.
- W2173990921 cites W2046378189 @default.
- W2173990921 cites W2049143824 @default.
- W2173990921 cites W2049441409 @default.
- W2173990921 cites W2056187832 @default.
- W2173990921 cites W2058059788 @default.
- W2173990921 cites W2059308833 @default.
- W2173990921 cites W2062093519 @default.
- W2173990921 cites W2066139702 @default.
- W2173990921 cites W2072220916 @default.
- W2173990921 cites W2073206710 @default.
- W2173990921 cites W2077817551 @default.
- W2173990921 cites W2079428657 @default.
- W2173990921 cites W2082190201 @default.
- W2173990921 cites W2086740410 @default.
- W2173990921 cites W2086787559 @default.
- W2173990921 cites W2093891993 @default.
- W2173990921 cites W2102496376 @default.
- W2173990921 cites W2103561861 @default.
- W2173990921 cites W2105102381 @default.
- W2173990921 cites W2105803743 @default.
- W2173990921 cites W2108027291 @default.
- W2173990921 cites W2112652913 @default.
- W2173990921 cites W2123858532 @default.
- W2173990921 cites W2127890285 @default.
- W2173990921 cites W2132071754 @default.
- W2173990921 cites W2135063296 @default.
- W2173990921 cites W2135293796 @default.
- W2173990921 cites W2138398380 @default.
- W2173990921 cites W2141346295 @default.
- W2173990921 cites W2145359198 @default.
- W2173990921 cites W2146839662 @default.
- W2173990921 cites W2152021942 @default.
- W2173990921 cites W2155492919 @default.
- W2173990921 cites W2165565225 @default.
- W2173990921 cites W2165751353 @default.
- W2173990921 cites W2166512828 @default.
- W2173990921 cites W2168309258 @default.
- W2173990921 cites W2169022387 @default.
- W2173990921 cites W4293107615 @default.
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- W2173990921 doi "https://doi.org/10.1016/j.bbr.2015.11.006" @default.
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- W2173990921 hasPublicationYear "2016" @default.
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