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• W2174001423 abstract "A series of A-ring pyrrole derivatives of duocarmycin bearing beta-(5',6',7'-trimethoxy-2'-indolyl)acryloyl group were synthesized, and evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity against murine sarcoma 180 in mice. New Seg-B analogues bearing beta-(5',6',7'-trimethoxy-2'-indolyl)acryloyl group containing double bond as spacer had lower peripheral blood toxicity than the derivatives bearing 5',6',7'-trimethoxyindole-2'-carboxyl group in Seg-B of the natural type. Moreover, most of them exhibited potent antitumor activity against in vivo murine tumor models." @default.
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• W2174001423 date "2000-07-01" @default.
• W2174001423 modified "2023-09-27" @default.
• W2174001423 title "Synthesis and antitumor activity of duocarmycin derivatives" @default.
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• W2174001423 doi "https://doi.org/10.1016/s0968-0896(00)00086-9" @default.
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