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- W2174028532 endingPage "1101" @default.
- W2174028532 startingPage "1095" @default.
- W2174028532 abstract "Caffeic acid phenethyl ester (CAPE) is an active component of honeybee propolis extracts. Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread and intensively studied metalloenzymes present in higher vertebrates including humans as many diverse isoforms. Acetylcholinesterase (AChE) is responsible for acetyl choline (ACh) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ACh neurotransmitter at cholinergic synapses and neuromuscular junctions. Butyrylcholinesterase (BChE) is another enzyme abundantly present in the liver and released into blood in a soluble form. Lactoperoxidase (LPO) is an enzyme involved in fighting pathogenic microorganisms whereas glutathione S-transferases (GSTs) are dimeric proteins present both in prokaryotic and eukaryotic organisms and involved in cellular detoxification mechanisms. In the present study, the inhibition effect of CAPE on human carbonic anhydrase (hCA) isoforms I, II, IX, and XII, AChE, BChE, LPO, and GST was evaluated. CAPE inhibited these enzymes with Kis in the range between micromolar to picomolar. The best inhibitory effect was observed against AChE and BChE." @default.
- W2174028532 created "2016-06-24" @default.
- W2174028532 creator A5032563690 @default.
- W2174028532 creator A5035013697 @default.
- W2174028532 creator A5045109010 @default.
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- W2174028532 creator A5054467099 @default.
- W2174028532 creator A5056677681 @default.
- W2174028532 creator A5086011099 @default.
- W2174028532 date "2015-10-09" @default.
- W2174028532 modified "2023-10-01" @default.
- W2174028532 title "The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII" @default.
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