FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174135220> ?p ?o ?g. }

• W2174135220 endingPage "1675" @default.
• W2174135220 startingPage "1654" @default.
• W2174135220 abstract "In this paper, we present a unified modeling framework to combine aggregated data from randomized controlled trials (RCTs) with individual participant data (IPD) from observational studies. Rather than simply pooling the available evidence into an overall treatment effect, adjusted for potential confounding, the intention of this work is to explore treatment effects in specific patient populations reflected by the IPD. In this way, by collecting IPD, we can potentially gain new insights from RCTs' results, which cannot be seen using only a meta‐analysis of RCTs. We present a new Bayesian hierarchical meta‐regression model, which combines submodels, representing different types of data into a coherent analysis. Predictors of baseline risk are estimated from the individual data. Simultaneously, a bivariate random effects distribution of baseline risk and treatment effects is estimated from the combined individual and aggregate data. Therefore, given a subgroup of interest, the estimated treatment effect can be calculated through its correlation with baseline risk. We highlight different types of model parameters: those that are the focus of inference (e.g., treatment effect in a subgroup of patients) and those that are used to adjust for biases introduced by data collection processes (e.g., internal or external validity). The model is applied to a case study where RCTs' results, investigating efficacy in the treatment of diabetic foot problems, are extrapolated to groups of patients treated in medical routine and who were enrolled in a prospective cohort study. Copyright © 2015 John Wiley & Sons, Ltd." @default.
• W2174135220 created "2016-06-24" @default.
• W2174135220 creator A5017752855 @default.
• W2174135220 creator A5050344020 @default.
• W2174135220 creator A5066489446 @default.
• W2174135220 creator A5079031621 @default.
• W2174135220 date "2015-11-22" @default.
• W2174135220 modified "2023-10-16" @default.
• W2174135220 title "Bayesian evidence synthesis for exploring generalizability of treatment effects: a case study of combining randomized and non‐randomized results in diabetes" @default.
• W2174135220 cites W1536497620 @default.
• W2174135220 cites W1580781770 @default.
• W2174135220 cites W1803108444 @default.
• W2174135220 cites W1918813775 @default.
• W2174135220 cites W1966411627 @default.
• W2174135220 cites W1981501248 @default.
• W2174135220 cites W1982319419 @default.
• W2174135220 cites W1995385610 @default.
• W2174135220 cites W2017541934 @default.
• W2174135220 cites W2019457874 @default.
• W2174135220 cites W2042304363 @default.
• W2174135220 cites W2043349008 @default.
• W2174135220 cites W2049057031 @default.
• W2174135220 cites W2049552036 @default.
• W2174135220 cites W2059416611 @default.
• W2174135220 cites W2062040186 @default.
• W2174135220 cites W2064790346 @default.
• W2174135220 cites W2080191652 @default.
• W2174135220 cites W2099610513 @default.
• W2174135220 cites W2100170944 @default.
• W2174135220 cites W2102386709 @default.
• W2174135220 cites W2104478709 @default.
• W2174135220 cites W2109632681 @default.
• W2174135220 cites W2112281477 @default.
• W2174135220 cites W2115097946 @default.
• W2174135220 cites W2125097889 @default.
• W2174135220 cites W2126629865 @default.
• W2174135220 cites W2128333437 @default.
• W2174135220 cites W2131750115 @default.
• W2174135220 cites W2134012062 @default.
• W2174135220 cites W2136986719 @default.
• W2174135220 cites W2150718275 @default.
• W2174135220 cites W2152763590 @default.
• W2174135220 cites W2163174010 @default.
• W2174135220 cites W2167144043 @default.
• W2174135220 cites W2169300691 @default.
• W2174135220 cites W2170205796 @default.
• W2174135220 cites W2171544285 @default.
• W2174135220 cites W3105019151 @default.
• W2174135220 cites W4230665555 @default.
• W2174135220 doi "https://doi.org/10.1002/sim.6809" @default.
• W2174135220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26593632" @default.
• W2174135220 hasPublicationYear "2015" @default.
• W2174135220 type Work @default.
• W2174135220 sameAs 2174135220 @default.
• W2174135220 citedByCount "14" @default.
• W2174135220 countsByYear W21741352202014 @default.
• W2174135220 countsByYear W21741352202017 @default.
• W2174135220 countsByYear W21741352202018 @default.
• W2174135220 countsByYear W21741352202019 @default.
• W2174135220 countsByYear W21741352202020 @default.
• W2174135220 countsByYear W21741352202022 @default.
• W2174135220 countsByYear W21741352202023 @default.
• W2174135220 crossrefType "journal-article" @default.
• W2174135220 hasAuthorship W2174135220A5017752855 @default.
• W2174135220 hasAuthorship W2174135220A5050344020 @default.
• W2174135220 hasAuthorship W2174135220A5066489446 @default.
• W2174135220 hasAuthorship W2174135220A5079031621 @default.
• W2174135220 hasConcept C100480397 @default.
• W2174135220 hasConcept C105795698 @default.
• W2174135220 hasConcept C107673813 @default.
• W2174135220 hasConcept C126322002 @default.
• W2174135220 hasConcept C149782125 @default.
• W2174135220 hasConcept C154945302 @default.
• W2174135220 hasConcept C168563851 @default.
• W2174135220 hasConcept C168743327 @default.
• W2174135220 hasConcept C187960798 @default.
• W2174135220 hasConcept C23131810 @default.
• W2174135220 hasConcept C27158222 @default.
• W2174135220 hasConcept C33923547 @default.
• W2174135220 hasConcept C41008148 @default.
• W2174135220 hasConcept C64341305 @default.
• W2174135220 hasConcept C70437156 @default.
• W2174135220 hasConcept C71924100 @default.
• W2174135220 hasConcept C77350462 @default.
• W2174135220 hasConcept C95190672 @default.
• W2174135220 hasConceptScore W2174135220C100480397 @default.
• W2174135220 hasConceptScore W2174135220C105795698 @default.
• W2174135220 hasConceptScore W2174135220C107673813 @default.
• W2174135220 hasConceptScore W2174135220C126322002 @default.
• W2174135220 hasConceptScore W2174135220C149782125 @default.
• W2174135220 hasConceptScore W2174135220C154945302 @default.
• W2174135220 hasConceptScore W2174135220C168563851 @default.
• W2174135220 hasConceptScore W2174135220C168743327 @default.
• W2174135220 hasConceptScore W2174135220C187960798 @default.
• W2174135220 hasConceptScore W2174135220C23131810 @default.
• W2174135220 hasConceptScore W2174135220C27158222 @default.
• W2174135220 hasConceptScore W2174135220C33923547 @default.
• W2174135220 hasConceptScore W2174135220C41008148 @default.

• next