FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174179281> ?p ?o ?g. }

• W2174179281 endingPage "192" @default.
• W2174179281 startingPage "185" @default.
• W2174179281 abstract "Sequence type (ST) 239 with SCCmec type III methicillin-resistant Staphylococcus aureus (ST239-MRSA-III) is the most predominant multidrug-resistant clone in China. The subclone ST239-MRSA-III-t037 has been gradually replaced with ST239-MRSA-III-t030 since 2000. Subclones are characterized by drug resistance profiles. However, the mechanisms of the clonal dynamics and determinants of distinct drug resistance remain poorly understood. In the present study, 12 ST239-MRSA-III-t030 and 12 ST239-MRSA-III-t037 strains were collected from Chongqing, Guangzhou, and Shanghai; these strains were selected and investigated in terms of t030/t037 strain pairs. Independent growth curve assay revealed that the ST239-MRSA-III-t030 strains grew more rapidly, with significantly shorter doubling times, than the ST239-MRSA-III-t037 strains (p < 0.001). The ST239-MRSA-III-t037 strains exhibited slightly to moderately higher (3-13%) fitness cost than the ST239-MRSA-III-t030 strains in a competition assay in vitro. The ST239-MRSA-III-t037 strains yielded lower bacterial loads in the kidneys of the infected mice than the ST239-MRSA-III-t030 rivals in a coinfection assay (p < 0.05). The ST239-MRSA-III-t030 strains were resistant to rifampicin but susceptible to trimethoprim/sulfamethoxazole (SXT). In contrast, the ST239-MRSA-III-t037 strains were susceptible to rifampicin but resistant to SXT. The genetic determinants of the resistance to rifampicin and SXT in the MRSA strains were determined. Our results suggest that the relatively low fitness cost and characteristic drug resistance phenotype can help explain the current predominance of these ST239-MRSA-III-t030 strains in Chinese hospitals." @default.
• W2174179281 created "2016-06-24" @default.
• W2174179281 creator A5001647048 @default.
• W2174179281 creator A5007238584 @default.
• W2174179281 creator A5040236818 @default.
• W2174179281 creator A5042914920 @default.
• W2174179281 creator A5045907730 @default.
• W2174179281 creator A5062492017 @default.
• W2174179281 creator A5062517279 @default.
• W2174179281 creator A5065510687 @default.
• W2174179281 creator A5066532319 @default.
• W2174179281 creator A5072823050 @default.
• W2174179281 creator A5074864845 @default.
• W2174179281 creator A5077218020 @default.
• W2174179281 creator A5077231460 @default.
• W2174179281 creator A5089923830 @default.
• W2174179281 date "2016-04-01" @default.
• W2174179281 modified "2023-10-16" @default.
• W2174179281 title "Comparative Fitness and Determinants for the Characteristic Drug Resistance of ST239-MRSA-III-t030 and ST239-MRSA-III-t037 Strains Isolated in China" @default.
• W2174179281 cites W1979953118 @default.
• W2174179281 cites W1980030331 @default.
• W2174179281 cites W1990621832 @default.
• W2174179281 cites W2004498777 @default.
• W2174179281 cites W2017870685 @default.
• W2174179281 cites W2031480338 @default.
• W2174179281 cites W2034166141 @default.
• W2174179281 cites W2046589125 @default.
• W2174179281 cites W2064600737 @default.
• W2174179281 cites W2065606193 @default.
• W2174179281 cites W2078221114 @default.
• W2174179281 cites W2082416657 @default.
• W2174179281 cites W2095820657 @default.
• W2174179281 cites W2096008171 @default.
• W2174179281 cites W2101134401 @default.
• W2174179281 cites W2103266884 @default.
• W2174179281 cites W2104534000 @default.
• W2174179281 cites W2109136149 @default.
• W2174179281 cites W2109241296 @default.
• W2174179281 cites W2110512370 @default.
• W2174179281 cites W2119490605 @default.
• W2174179281 cites W2123578113 @default.
• W2174179281 cites W2137692381 @default.
• W2174179281 cites W2151047172 @default.
• W2174179281 cites W2151150074 @default.
• W2174179281 cites W2154858303 @default.
• W2174179281 cites W2156450233 @default.
• W2174179281 cites W2158353565 @default.
• W2174179281 cites W2159308620 @default.
• W2174179281 cites W2161102427 @default.
• W2174179281 cites W2164597071 @default.
• W2174179281 cites W2165195087 @default.
• W2174179281 doi "https://doi.org/10.1089/mdr.2015.0226" @default.
• W2174179281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26565599" @default.
• W2174179281 hasPublicationYear "2016" @default.
• W2174179281 type Work @default.
• W2174179281 sameAs 2174179281 @default.
• W2174179281 citedByCount "28" @default.
• W2174179281 countsByYear W21741792812016 @default.
• W2174179281 countsByYear W21741792812017 @default.
• W2174179281 countsByYear W21741792812018 @default.
• W2174179281 countsByYear W21741792812019 @default.
• W2174179281 countsByYear W21741792812020 @default.
• W2174179281 countsByYear W21741792812021 @default.
• W2174179281 countsByYear W21741792812022 @default.
• W2174179281 countsByYear W21741792812023 @default.
• W2174179281 crossrefType "journal-article" @default.
• W2174179281 hasAuthorship W2174179281A5001647048 @default.
• W2174179281 hasAuthorship W2174179281A5007238584 @default.
• W2174179281 hasAuthorship W2174179281A5040236818 @default.
• W2174179281 hasAuthorship W2174179281A5042914920 @default.
• W2174179281 hasAuthorship W2174179281A5045907730 @default.
• W2174179281 hasAuthorship W2174179281A5062492017 @default.
• W2174179281 hasAuthorship W2174179281A5062517279 @default.
• W2174179281 hasAuthorship W2174179281A5065510687 @default.
• W2174179281 hasAuthorship W2174179281A5066532319 @default.
• W2174179281 hasAuthorship W2174179281A5072823050 @default.
• W2174179281 hasAuthorship W2174179281A5074864845 @default.
• W2174179281 hasAuthorship W2174179281A5077218020 @default.
• W2174179281 hasAuthorship W2174179281A5077231460 @default.
• W2174179281 hasAuthorship W2174179281A5089923830 @default.
• W2174179281 hasConcept C114851261 @default.
• W2174179281 hasConcept C11701158 @default.
• W2174179281 hasConcept C133936738 @default.
• W2174179281 hasConcept C2777052132 @default.
• W2174179281 hasConcept C2778607973 @default.
• W2174179281 hasConcept C2779425571 @default.
• W2174179281 hasConcept C2779489039 @default.
• W2174179281 hasConcept C501593827 @default.
• W2174179281 hasConcept C523546767 @default.
• W2174179281 hasConcept C54355233 @default.
• W2174179281 hasConcept C86803240 @default.
• W2174179281 hasConcept C89423630 @default.
• W2174179281 hasConcept C94665300 @default.
• W2174179281 hasConceptScore W2174179281C114851261 @default.
• W2174179281 hasConceptScore W2174179281C11701158 @default.
• W2174179281 hasConceptScore W2174179281C133936738 @default.
• W2174179281 hasConceptScore W2174179281C2777052132 @default.
• W2174179281 hasConceptScore W2174179281C2778607973 @default.

• next