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- W2174191116 abstract "Since Dr. Fogh-Andersen's legendary 1942 thesis, the Danish facial cleft population has been one of the most extensively studied in terms of epidemiology and genetic-epidemiology. The etiology of cleft lip and/or palate (CLP) is still largely an enigma, and different results concerning environmental and genetic risk factors are obtained in different countries and regions. This may be due to etiological heterogeneity between settings. Therefore, an in-depth studied area with an ethnically homogeneous population, such as Denmark, has provided one of the best opportunities for progress in CLP etiological research. The present review summarizes epidemiological and genetic-epidemiological studies conducted in the 20th century Danish facial cleft population. Furthermore, analyses of sex differences, time trends and seasonality for more than 7000 CLP cases born in Denmark in the period 1936 to 1987 are presented. The review also points toward the excellent opportunities for continued etiological CLP research in Denmark in the 21st century using already established resources and an on-going prospective cohort study of 100,000 pregnant women." @default.
- W2174191116 created "2016-06-24" @default.
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- W2174191116 date "1999-03-01" @default.
- W2174191116 modified "2023-09-25" @default.
- W2174191116 title "The 20th Century Danish Facial Cleft Population—Epidemiological and Genetic-Epidemiological Studies" @default.
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- W2174191116 doi "https://doi.org/10.1597/1545-1569_1999_036_0096_tcdfcp_2.3.co_2" @default.
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