FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174195433> ?p ?o ?g. }

• W2174195433 endingPage "73" @default.
• W2174195433 startingPage "368" @default.
• W2174195433 abstract "Pathogens infecting mammalian cells have developed various strategies to suppress and evade their hosts' defensive mechanisms. In this line, the intracellular bacteria that are able to survive and propagate within their host cells must have developed strategies to avert their host's killing attitude. Studying the interface of host-pathogen confrontation can provide valuable information for defining therapeutic approaches. Brucellosis, caused by the Brucella strains, is a zoonotic bacterial disease that affects thousands of humans and animals around the world inflicting discomfort and huge economic losses. Similar to many other intracellular dwelling bacteria, infections caused by Brucella are difficult to treat, and hence any attempt at identifying new and common therapeutic targets would prove beneficial for the purpose of curing infections caused by the intracellular bacteria. In THP-1 macrophage infected with Brucella melitensis we studied the expression levels of four host's genes, i.e. EMP2, ST8SIA4, HCP5 and FRMD5 known to be involved in pathogenesis of Mycobacterium tuberculosis. Our data showed that at this molecular level, except for FRMD5 that was downregulated, the other three genes were upregulated by B. melitensis. Brucella melitensis and M. tuberculosis go through similar intracellular processes and interestingly two of the investigated genes, i.e. EMP2 and ST4SIA8 were upregulated in THP-1 cell infected with B. melitensis similar to that reported for THP-1 cells infected with M. tuberculosis. At the host-pathogen interaction interface, this study depicts overlapping changes for different bacteria with common survival strategies; a fact that implies designing therapeutic approaches based on common targets may be possible." @default.
• W2174195433 created "2016-06-24" @default.
• W2174195433 creator A5048316219 @default.
• W2174195433 creator A5050574913 @default.
• W2174195433 creator A5069918997 @default.
• W2174195433 date "2015-01-01" @default.
• W2174195433 modified "2023-09-23" @default.
• W2174195433 title "Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1 macrophages." @default.
• W2174195433 cites W1685737327 @default.
• W2174195433 cites W1967659496 @default.
• W2174195433 cites W1986413607 @default.
• W2174195433 cites W1996148443 @default.
• W2174195433 cites W1996747267 @default.
• W2174195433 cites W2012034410 @default.
• W2174195433 cites W2012451546 @default.
• W2174195433 cites W2015410697 @default.
• W2174195433 cites W2021681950 @default.
• W2174195433 cites W2028016637 @default.
• W2174195433 cites W2036735937 @default.
• W2174195433 cites W2041565635 @default.
• W2174195433 cites W2042289037 @default.
• W2174195433 cites W2050944592 @default.
• W2174195433 cites W2052066361 @default.
• W2174195433 cites W2056607892 @default.
• W2174195433 cites W2060066878 @default.
• W2174195433 cites W2064750958 @default.
• W2174195433 cites W2076864491 @default.
• W2174195433 cites W2084693908 @default.
• W2174195433 cites W2085104810 @default.
• W2174195433 cites W2085402247 @default.
• W2174195433 cites W2091015733 @default.
• W2174195433 cites W2099249565 @default.
• W2174195433 cites W2111222049 @default.
• W2174195433 cites W2119057012 @default.
• W2174195433 cites W2119752906 @default.
• W2174195433 cites W2120692442 @default.
• W2174195433 cites W2123584222 @default.
• W2174195433 cites W2142622505 @default.
• W2174195433 cites W2146980885 @default.
• W2174195433 cites W2156601706 @default.
• W2174195433 cites W2162098634 @default.
• W2174195433 cites W2168783124 @default.
• W2174195433 cites W2324042516 @default.
• W2174195433 cites W1986363529 @default.
• W2174195433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4782677" @default.
• W2174195433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27175205" @default.
• W2174195433 hasPublicationYear "2015" @default.
• W2174195433 type Work @default.
• W2174195433 sameAs 2174195433 @default.
• W2174195433 citedByCount "3" @default.
• W2174195433 countsByYear W21741954332017 @default.
• W2174195433 countsByYear W21741954332020 @default.
• W2174195433 countsByYear W21741954332023 @default.
• W2174195433 crossrefType "journal-article" @default.
• W2174195433 hasAuthorship W2174195433A5048316219 @default.
• W2174195433 hasAuthorship W2174195433A5050574913 @default.
• W2174195433 hasAuthorship W2174195433A5069918997 @default.
• W2174195433 hasConcept C104317684 @default.
• W2174195433 hasConcept C142724271 @default.
• W2174195433 hasConcept C153726182 @default.
• W2174195433 hasConcept C159047783 @default.
• W2174195433 hasConcept C2776460866 @default.
• W2174195433 hasConcept C2777692091 @default.
• W2174195433 hasConcept C2777975735 @default.
• W2174195433 hasConcept C2780767784 @default.
• W2174195433 hasConcept C2781069245 @default.
• W2174195433 hasConcept C2781429187 @default.
• W2174195433 hasConcept C523546767 @default.
• W2174195433 hasConcept C54355233 @default.
• W2174195433 hasConcept C71924100 @default.
• W2174195433 hasConcept C79879829 @default.
• W2174195433 hasConcept C86803240 @default.
• W2174195433 hasConcept C89423630 @default.
• W2174195433 hasConceptScore W2174195433C104317684 @default.
• W2174195433 hasConceptScore W2174195433C142724271 @default.
• W2174195433 hasConceptScore W2174195433C153726182 @default.
• W2174195433 hasConceptScore W2174195433C159047783 @default.
• W2174195433 hasConceptScore W2174195433C2776460866 @default.
• W2174195433 hasConceptScore W2174195433C2777692091 @default.
• W2174195433 hasConceptScore W2174195433C2777975735 @default.
• W2174195433 hasConceptScore W2174195433C2780767784 @default.
• W2174195433 hasConceptScore W2174195433C2781069245 @default.
• W2174195433 hasConceptScore W2174195433C2781429187 @default.
• W2174195433 hasConceptScore W2174195433C523546767 @default.
• W2174195433 hasConceptScore W2174195433C54355233 @default.
• W2174195433 hasConceptScore W2174195433C71924100 @default.
• W2174195433 hasConceptScore W2174195433C79879829 @default.
• W2174195433 hasConceptScore W2174195433C86803240 @default.
• W2174195433 hasConceptScore W2174195433C89423630 @default.
• W2174195433 hasIssue "4" @default.
• W2174195433 hasLocation W21741954331 @default.
• W2174195433 hasOpenAccess W2174195433 @default.
• W2174195433 hasPrimaryLocation W21741954331 @default.
• W2174195433 hasRelatedWork W1828244226 @default.
• W2174195433 hasRelatedWork W2087012859 @default.
• W2174195433 hasRelatedWork W2091214854 @default.
• W2174195433 hasRelatedWork W2122258611 @default.
• W2174195433 hasRelatedWork W2174195433 @default.

• next