FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174255710> ?p ?o ?g. }

• W2174255710 endingPage "586" @default.
• W2174255710 startingPage "581" @default.
• W2174255710 abstract "Because immune responses to DNA vaccines in humans remains suboptimal, strategies need to be devised to facilitate expression of the vaccine in vivo. One method to improve response to a DNA vaccine is to construct plasmid vectors with leader sequences and post-transcriptional elements that facilitate export of transcribed RNA. In this study, we sought to determine if a mammalian expression vector (pND-14) containing a tissue plasminogen activator (TPA) leader sequence and a constitutive transport element (CTE) from simian retrovirus was superior to other mammalian expression vectors containing a post-transcriptional regulatory element (PRE) from hepatitis B virus (pCMV-link) or a minimal mammalian expression vector (pVAX1). Toward this objective, we evaluated protein expression of the HIV-2 envelope gene (gp140) in vitro and immune responses in immunized mice. We found that pVAX1 produced three- to fourfold lower levels of gp140 in vitro (5 ng/ml) in contrast to the pCMV-link and pND-14 vectors. When we immunized groups of mice intradermally with two of the HIV-2 gp140 DNA vaccine constructs, we found that pND-14 induced higher levels of envelope-specific systemic and mucosal antibodies than pCMV-link. We conclude that expression vectors for DNA vaccines should contain TPA and CTE sequences to facilitate immune responses." @default.
• W2174255710 created "2016-06-24" @default.
• W2174255710 creator A5006199434 @default.
• W2174255710 creator A5032352295 @default.
• W2174255710 creator A5070921348 @default.
• W2174255710 creator A5077818732 @default.
• W2174255710 date "2002-08-01" @default.
• W2174255710 modified "2023-09-24" @default.
• W2174255710 title "Enhancement of Antibody Responses to an HIV-2 DNA Envelope Vaccine Using an Expression Vector Containing a Constitutive Transport Element" @default.
• W2174255710 cites W1967680682 @default.
• W2174255710 cites W1975849308 @default.
• W2174255710 cites W1987016144 @default.
• W2174255710 cites W1991933020 @default.
• W2174255710 cites W2024171686 @default.
• W2174255710 cites W2027314001 @default.
• W2174255710 cites W2027970402 @default.
• W2174255710 cites W2031598154 @default.
• W2174255710 cites W2049400853 @default.
• W2174255710 cites W2056377358 @default.
• W2174255710 cites W2056568415 @default.
• W2174255710 cites W2056877436 @default.
• W2174255710 cites W2067228485 @default.
• W2174255710 cites W2074872575 @default.
• W2174255710 cites W2087395692 @default.
• W2174255710 cites W2089478501 @default.
• W2174255710 cites W2092083108 @default.
• W2174255710 cites W2101581475 @default.
• W2174255710 cites W2126238684 @default.
• W2174255710 cites W2129166390 @default.
• W2174255710 cites W2131974188 @default.
• W2174255710 cites W2136511955 @default.
• W2174255710 cites W2144725211 @default.
• W2174255710 cites W2149791183 @default.
• W2174255710 cites W2152100889 @default.
• W2174255710 cites W2156521514 @default.
• W2174255710 cites W2158798674 @default.
• W2174255710 cites W2166240517 @default.
• W2174255710 cites W2402190721 @default.
• W2174255710 cites W2408371894 @default.
• W2174255710 cites W2409363532 @default.
• W2174255710 cites W2414182524 @default.
• W2174255710 doi "https://doi.org/10.1089/104454902320308951" @default.
• W2174255710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12215261" @default.
• W2174255710 hasPublicationYear "2002" @default.
• W2174255710 type Work @default.
• W2174255710 sameAs 2174255710 @default.
• W2174255710 citedByCount "7" @default.
• W2174255710 crossrefType "journal-article" @default.
• W2174255710 hasAuthorship W2174255710A5006199434 @default.
• W2174255710 hasAuthorship W2174255710A5032352295 @default.
• W2174255710 hasAuthorship W2174255710A5070921348 @default.
• W2174255710 hasAuthorship W2174255710A5077818732 @default.
• W2174255710 hasConcept C104317684 @default.
• W2174255710 hasConcept C150194340 @default.
• W2174255710 hasConcept C153911025 @default.
• W2174255710 hasConcept C159047783 @default.
• W2174255710 hasConcept C167508917 @default.
• W2174255710 hasConcept C203014093 @default.
• W2174255710 hasConcept C22744801 @default.
• W2174255710 hasConcept C2522874641 @default.
• W2174255710 hasConcept C2778431562 @default.
• W2174255710 hasConcept C32470452 @default.
• W2174255710 hasConcept C33161422 @default.
• W2174255710 hasConcept C40767141 @default.
• W2174255710 hasConcept C54355233 @default.
• W2174255710 hasConcept C86803240 @default.
• W2174255710 hasConcept C8891405 @default.
• W2174255710 hasConcept C92087593 @default.
• W2174255710 hasConceptScore W2174255710C104317684 @default.
• W2174255710 hasConceptScore W2174255710C150194340 @default.
• W2174255710 hasConceptScore W2174255710C153911025 @default.
• W2174255710 hasConceptScore W2174255710C159047783 @default.
• W2174255710 hasConceptScore W2174255710C167508917 @default.
• W2174255710 hasConceptScore W2174255710C203014093 @default.
• W2174255710 hasConceptScore W2174255710C22744801 @default.
• W2174255710 hasConceptScore W2174255710C2522874641 @default.
• W2174255710 hasConceptScore W2174255710C2778431562 @default.
• W2174255710 hasConceptScore W2174255710C32470452 @default.
• W2174255710 hasConceptScore W2174255710C33161422 @default.
• W2174255710 hasConceptScore W2174255710C40767141 @default.
• W2174255710 hasConceptScore W2174255710C54355233 @default.
• W2174255710 hasConceptScore W2174255710C86803240 @default.
• W2174255710 hasConceptScore W2174255710C8891405 @default.
• W2174255710 hasConceptScore W2174255710C92087593 @default.
• W2174255710 hasIssue "8" @default.
• W2174255710 hasLocation W21742557101 @default.
• W2174255710 hasLocation W21742557102 @default.
• W2174255710 hasOpenAccess W2174255710 @default.
• W2174255710 hasPrimaryLocation W21742557101 @default.
• W2174255710 hasRelatedWork W1511818607 @default.
• W2174255710 hasRelatedWork W1844229196 @default.
• W2174255710 hasRelatedWork W2047896367 @default.
• W2174255710 hasRelatedWork W2174255710 @default.
• W2174255710 hasRelatedWork W2262907345 @default.
• W2174255710 hasRelatedWork W2357549339 @default.
• W2174255710 hasRelatedWork W2366804025 @default.
• W2174255710 hasRelatedWork W2385797964 @default.
• W2174255710 hasRelatedWork W2390062883 @default.

• next