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• W2174282801 abstract "Summary Bacterial morphology is determined primarily by the architecture of the peptidoglycan ( PG ) cell wall, a mesh‐like layer that encases the cell. To identify novel mechanisms that create or maintain cell shape in E scherichia coli , we used flow cytometry to screen a transposon insertion library and identified a wec E mutant that altered cell shape, causing cells to filament and swell. WecE is a sugar aminotransferase involved in the biosynthesis of enterobacterial common antigen ( ECA ), a non‐essential outer membrane glycolipid of the E nterobacteriaceae . Loss of wec E interrupts biosynthesis of ECA and causes the accumulation of the undecaprenyl pyrophosphate‐linked intermediate ECA ‐lipid II . The wec E shape defects were reversed by: (i) preventing initiation of ECA biosynthesis, (ii) increasing the synthesis of the lipid carrier undecaprenyl phosphate ( U nd‐ P ), (iii) diverting U nd‐ P to PG synthesis or (iv) promoting U nd‐ P recycling. The results argue that the buildup of ECA ‐lipid II sequesters part of the pool of U nd‐ P , which, in turn, adversely affects PG synthesis. The data strongly suggest there is competition for a common pool of U nd‐ P , whose proper distribution to alternate metabolic pathways is required to maintain normal cell shape in E . coli ." @default.
• W2174282801 created "2016-06-24" @default.
• W2174282801 creator A5037125732 @default.
• W2174282801 creator A5076780896 @default.
• W2174282801 creator A5079189889 @default.
• W2174282801 creator A5082193743 @default.
• W2174282801 date "2015-12-22" @default.
• W2174282801 modified "2023-10-03" @default.
• W2174282801 title "Dead-end intermediates in the enterobacterial common antigen pathway induce morphological defects in<i>Escherichia coli</i>by competing for undecaprenyl phosphate" @default.
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• W2174282801 doi "https://doi.org/10.1111/mmi.13284" @default.
• W2174282801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4845916" @default.
• W2174282801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26593043" @default.
• W2174282801 hasPublicationYear "2015" @default.
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