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- W2174328991 abstract "Background . This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5 −/− ), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice. Results . TLR5 −/− and C57BL/6 male mice were divided into three subgroups: (1) control, mice were fed a standard AIN-76A (fat: 11.5 kcal%) diet for 12 weeks; (2) DIO, mice were fed a 58 kcal% high-fat diet (HFD) for 12 weeks; and (3) diet, mice were fed a HFD for 8 weeks to induce obesity and then switched to a 10.5 kcal% LFD for 4 weeks. The glucose intolerance in DIO TLR5 −/− mice was more significant than that in DIO C57BL/6 mice and was not attenuated by a switch to the LFD. Weight-reduction with LFD had significantly decreased the epididymal fat mass in C57BL/6 mice but not in TLR5 −/− mice. In addition, the LFD-fed TLR5 −/− mice showed significantly higher expression of ghrelin in the serum and resistin in the epididymal fat than that in C57BL/6 mice. Conclusions . This study demonstrated that TLR5 gene knockout impairs some effects of weight-reduction in DIO." @default.
- W2174328991 created "2016-06-24" @default.
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- W2174328991 date "2015-01-01" @default.
- W2174328991 modified "2023-10-16" @default.
- W2174328991 title "Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL/6 Mice Fed a Low-Fat Diet" @default.
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- W2174328991 doi "https://doi.org/10.1155/2015/852126" @default.
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