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- W2174332318 abstract "1,2,4-Oxadiazolidin-3,5-dione and 1,3,5-triazin-2,4,6-trione scaffolds were employed as templates to incorporate the pharmacophore requirements of cytosolic phospholipase A2alpha substrate mimetics. Inhibitors that are active in both enzyme, and cell-based assays were identified from both classes. From the SAR work carried out and modeling efforts around these templates, the triazinetrione scaffold with an additional substitution point was found to be more favorable." @default.
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- W2174332318 date "2006-06-01" @default.
- W2174332318 modified "2023-09-26" @default.
- W2174332318 title "1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors" @default.
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- W2174332318 doi "https://doi.org/10.1016/j.bmcl.2006.02.067" @default.
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