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- W2174332383 abstract "Since the commercialization of polydioxanone (PDX) as a biodegradable monofilament suture by Ethicon in 1981, the polymer has received only limited interest until recently. The limitations of polylactide-co-glycolide (PLGA) coupled with the growing need for materials with enhanced features and the advent of new fabrication techniques such as electrospinning have revived interest for PDX in medical devices, tissue engineering and drug delivery applications. Electrospun PDX mats show comparable mechanical properties as the major structural components of native vascular extracellular matrix (ECM) i.e. collagen and elastin. In addition, PDX's unique shape memory property provides rebound and kink resistance when fabricated into vascular conduits. The synthesis of methyl dioxanone (MeDX) monomer and copolymers of dioxanone (DX) and MeDX have opened up new perspectives for poly(ester-ether)s, enabling the design of the next generation of tissue engineering scaffolds for application in regenerating such tissues as arteries, peripheral nerve and bone. Tailoring of polymer properties and their formulation as nanoparticles, nanomicelles or nanofibers have brought along important developments in the area of controlled drug or gene delivery. This paper reviews the synthesis of PDX and its copolymers and provides for the first time an exhaustive account of its applications in the (bio)medical field with focus on tissue engineering and drug/gene delivery." @default.
- W2174332383 created "2016-06-24" @default.
- W2174332383 creator A5023321591 @default.
- W2174332383 creator A5036691731 @default.
- W2174332383 creator A5071672763 @default.
- W2174332383 creator A5078077122 @default.
- W2174332383 date "2015-11-01" @default.
- W2174332383 modified "2023-10-16" @default.
- W2174332383 title "Polydioxanone-based bio-materials for tissue engineering and drug/gene delivery applications" @default.
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- W2174332383 doi "https://doi.org/10.1016/j.ejpb.2015.05.024" @default.
- W2174332383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26614558" @default.
- W2174332383 hasPublicationYear "2015" @default.
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