FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174334940> ?p ?o ?g. }

• W2174334940 endingPage "733" @default.
• W2174334940 startingPage "721" @default.
• W2174334940 abstract "Gauter, B., Zlobinskaya, O. and Weber, K. J. Rejoining of Radiation-Induced DNA Double-Strand Breaks: Pulsed-Field Electrophoresis Analysis of Fragment Size Distributions after Incubation for Repair. Radiat. Res. 157, 721–733 (2002).The repair of radiation-induced DNA double-strand breaks (DSBs) is frequently investigated by measuring the time-dependent decrease in the fraction of fragmented DNA that is able to enter electrophoresis gels. When transformed into equivalent doses without repair, such measurements are thought to reflect the removal of DSBs, and they typically exhibit a fast initial component and a decreasing rate at longer repair intervals. This formalism, however, assumes that the spatial distribution of unrejoined breakage resembles the pattern of induction of DSBs. While the size distributions for initial fragmentation, such as that resolved by conventional pulsed-field gel electrophoresis (PFGE) (between about 105 and 107 bp), are well known to agree with the prediction of random breakage, no data are available from studies explicitly testing this relationship for residual breakage. Therefore, Chinese hamster V79 cells and MeWo (human melanoma) cells were irradiated with different doses (10–100 Gy) or were incubated for repair for up to 4 h after a single dose of 100 Gy (V79) or 90 Gy (MeWo) before being subjected to PFGE. Fragment size distributions were calculated by convolution of the PFGE profiles with an appropriately generated size calibration function. The results clearly demonstrate an over-representation of smaller fragments (below about 2–3 Mbp) compared to the prediction of randomness for residual breakage. In consequence, the time-dependent decrease of dose-equivalent values calculated from data on the fraction released may not directly reflect DSB rejoining rates. The present findings are compatible with an earlier suggestion of slow rejoining of breaks which have been induced as multiple breaks (two or more) in large chromosomal loops, thus also predicting an increase of the slowly rejoining DSB fraction with increasing dose." @default.
• W2174334940 created "2016-06-24" @default.
• W2174334940 creator A5007124108 @default.
• W2174334940 creator A5028401925 @default.
• W2174334940 creator A5071270019 @default.
• W2174334940 date "2002-06-01" @default.
• W2174334940 modified "2023-10-18" @default.
• W2174334940 title "Rejoining of Radiation-Induced DNA Double-Strand Breaks: Pulsed-Field Electrophoresis Analysis of Fragment Size Distributions after Incubation for Repair" @default.
• W2174334940 cites W1532833901 @default.
• W2174334940 cites W1750064874 @default.
• W2174334940 cites W1971687599 @default.
• W2174334940 cites W1976108918 @default.
• W2174334940 cites W1984889638 @default.
• W2174334940 cites W1995865760 @default.
• W2174334940 cites W1999471119 @default.
• W2174334940 cites W1999620843 @default.
• W2174334940 cites W2003689713 @default.
• W2174334940 cites W2007350044 @default.
• W2174334940 cites W2010594589 @default.
• W2174334940 cites W2013031696 @default.
• W2174334940 cites W2015444846 @default.
• W2174334940 cites W2019072372 @default.
• W2174334940 cites W2022929617 @default.
• W2174334940 cites W2023855077 @default.
• W2174334940 cites W2024604197 @default.
• W2174334940 cites W2038450079 @default.
• W2174334940 cites W2038889579 @default.
• W2174334940 cites W2041977470 @default.
• W2174334940 cites W2057832183 @default.
• W2174334940 cites W2061193270 @default.
• W2174334940 cites W2062375412 @default.
• W2174334940 cites W2068449224 @default.
• W2174334940 cites W2069202398 @default.
• W2174334940 cites W2075359803 @default.
• W2174334940 cites W2076068563 @default.
• W2174334940 cites W2088474558 @default.
• W2174334940 cites W2089935582 @default.
• W2174334940 cites W2098536022 @default.
• W2174334940 cites W2101356494 @default.
• W2174334940 cites W2101613112 @default.
• W2174334940 cites W2105648889 @default.
• W2174334940 cites W2109456773 @default.
• W2174334940 cites W2111137438 @default.
• W2174334940 cites W2113923653 @default.
• W2174334940 cites W2119100786 @default.
• W2174334940 cites W2127414222 @default.
• W2174334940 cites W2130728712 @default.
• W2174334940 cites W2134245262 @default.
• W2174334940 cites W2138460414 @default.
• W2174334940 cites W2138630142 @default.
• W2174334940 cites W2150964381 @default.
• W2174334940 cites W2170906160 @default.
• W2174334940 cites W2171262669 @default.
• W2174334940 cites W2315739987 @default.
• W2174334940 cites W2318222641 @default.
• W2174334940 cites W2323137659 @default.
• W2174334940 cites W2334018569 @default.
• W2174334940 cites W2413689709 @default.
• W2174334940 cites W4302445930 @default.
• W2174334940 doi "https://doi.org/10.1667/0033-7587(2002)157[0721:roridd]2.0.co;2" @default.
• W2174334940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12005552" @default.
• W2174334940 hasPublicationYear "2002" @default.
• W2174334940 type Work @default.
• W2174334940 sameAs 2174334940 @default.
• W2174334940 citedByCount "21" @default.
• W2174334940 countsByYear W21743349402013 @default.
• W2174334940 countsByYear W21743349402014 @default.
• W2174334940 countsByYear W21743349402015 @default.
• W2174334940 countsByYear W21743349402016 @default.
• W2174334940 countsByYear W21743349402019 @default.
• W2174334940 countsByYear W21743349402021 @default.
• W2174334940 countsByYear W21743349402022 @default.
• W2174334940 crossrefType "journal-article" @default.
• W2174334940 hasAuthorship W2174334940A5007124108 @default.
• W2174334940 hasAuthorship W2174334940A5028401925 @default.
• W2174334940 hasAuthorship W2174334940A5071270019 @default.
• W2174334940 hasConcept C104317684 @default.
• W2174334940 hasConcept C116084860 @default.
• W2174334940 hasConcept C12554922 @default.
• W2174334940 hasConcept C134935766 @default.
• W2174334940 hasConcept C135763542 @default.
• W2174334940 hasConcept C143425029 @default.
• W2174334940 hasConcept C153911025 @default.
• W2174334940 hasConcept C159985019 @default.
• W2174334940 hasConcept C18903297 @default.
• W2174334940 hasConcept C190283241 @default.
• W2174334940 hasConcept C191015642 @default.
• W2174334940 hasConcept C192562407 @default.
• W2174334940 hasConcept C2779015675 @default.
• W2174334940 hasConcept C31573885 @default.
• W2174334940 hasConcept C40250595 @default.
• W2174334940 hasConcept C42084846 @default.
• W2174334940 hasConcept C43759708 @default.
• W2174334940 hasConcept C54355233 @default.
• W2174334940 hasConcept C552990157 @default.
• W2174334940 hasConcept C86803240 @default.
• W2174334940 hasConceptScore W2174334940C104317684 @default.
• W2174334940 hasConceptScore W2174334940C116084860 @default.

• next