FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174359660> ?p ?o ?g. }

• W2174359660 endingPage "248" @default.
• W2174359660 startingPage "233" @default.
• W2174359660 abstract "The immunomodulatory and anti-inflammatory properties of mesenchymal stem cells (MSCs) have been proposed in several autoimmune diseases and successfully tested in animal models, but their contribution to psoriasis and underlying pathways remains elusive. Likewise, an increased or prolonged presence of reactive oxygen species and aberrant antioxidant systems in skin are known to contribute to the development of psoriasis and therefore effective antioxidant therapy is highly required. We explored the feasibility of using extracellular superoxide dismutase (SOD3)-transduced allogeneic MSCs as a novel therapeutic approach in a mouse model of imiquimod (IMQ)-induced psoriasis-like inflammation and investigated the poorly understood underlying mechanism. In addition, the chronicity and late-phase response of inflammation were evaluated during continued activation of antigen receptors by applying a booster dose of IMQ.Subcutaneous injection of allogeneic SOD3-transduced MSCs significantly prevented psoriasis development in our IMQ-induced mouse model, likely through a suppression of proliferation and infiltration of various effector cells into skin with a concomitant modulated cytokine and chemokine expression and inhibition of signaling pathways such as toll-like receptor-7, nuclear factor-kappa B, p38 mitogen-activated kinase, and Janus kinase-signal transducer and activator of transcription, as well as adenosine receptor activation.Our data offer a novel therapeutic approach to chronic inflammatory skin diseases such as psoriasis by leveraging immunomodulatory effects of MSCs as well as SOD3 expression." @default.
• W2174359660 created "2016-06-24" @default.
• W2174359660 creator A5013654282 @default.
• W2174359660 creator A5056411116 @default.
• W2174359660 creator A5085709514 @default.
• W2174359660 creator A5091602017 @default.
• W2174359660 date "2016-02-10" @default.
• W2174359660 modified "2023-10-18" @default.
• W2174359660 title "Effects of Human Mesenchymal Stem Cells Transduced with Superoxide Dismutase on Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice" @default.
• W2174359660 cites W1483815179 @default.
• W2174359660 cites W1532206496 @default.
• W2174359660 cites W1569338260 @default.
• W2174359660 cites W1846953774 @default.
• W2174359660 cites W1918751531 @default.
• W2174359660 cites W1929307843 @default.
• W2174359660 cites W1939997832 @default.
• W2174359660 cites W1968255500 @default.
• W2174359660 cites W1968536379 @default.
• W2174359660 cites W1976026615 @default.
• W2174359660 cites W1976588894 @default.
• W2174359660 cites W1977767980 @default.
• W2174359660 cites W1978370369 @default.
• W2174359660 cites W1979136553 @default.
• W2174359660 cites W1981622392 @default.
• W2174359660 cites W1982155401 @default.
• W2174359660 cites W1982408656 @default.
• W2174359660 cites W1989001888 @default.
• W2174359660 cites W1993046839 @default.
• W2174359660 cites W2001020866 @default.
• W2174359660 cites W2002437099 @default.
• W2174359660 cites W2004510831 @default.
• W2174359660 cites W2004956526 @default.
• W2174359660 cites W2011137808 @default.
• W2174359660 cites W2011870420 @default.
• W2174359660 cites W2016249583 @default.
• W2174359660 cites W2024326908 @default.
• W2174359660 cites W2024476229 @default.
• W2174359660 cites W2026791577 @default.
• W2174359660 cites W2028239901 @default.
• W2174359660 cites W2029097180 @default.
• W2174359660 cites W2034715647 @default.
• W2174359660 cites W2037827983 @default.
• W2174359660 cites W2050050144 @default.
• W2174359660 cites W2050524172 @default.
• W2174359660 cites W2057304280 @default.
• W2174359660 cites W2070555070 @default.
• W2174359660 cites W2071424821 @default.
• W2174359660 cites W2072510816 @default.
• W2174359660 cites W2074360288 @default.
• W2174359660 cites W2081002915 @default.
• W2174359660 cites W2082182811 @default.
• W2174359660 cites W2091656563 @default.
• W2174359660 cites W2101995250 @default.
• W2174359660 cites W2106621815 @default.
• W2174359660 cites W2113628816 @default.
• W2174359660 cites W2123555316 @default.
• W2174359660 cites W2133375451 @default.
• W2174359660 cites W2142920152 @default.
• W2174359660 cites W2143716911 @default.
• W2174359660 cites W2155729698 @default.
• W2174359660 cites W2158594521 @default.
• W2174359660 cites W2159358845 @default.
• W2174359660 cites W2159713247 @default.
• W2174359660 cites W2561759163 @default.
• W2174359660 cites W27810290 @default.
• W2174359660 cites W2414419752 @default.
• W2174359660 doi "https://doi.org/10.1089/ars.2015.6368" @default.
• W2174359660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4753626" @default.
• W2174359660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26462411" @default.
• W2174359660 hasPublicationYear "2016" @default.
• W2174359660 type Work @default.
• W2174359660 sameAs 2174359660 @default.
• W2174359660 citedByCount "53" @default.
• W2174359660 countsByYear W21743596602016 @default.
• W2174359660 countsByYear W21743596602017 @default.
• W2174359660 countsByYear W21743596602018 @default.
• W2174359660 countsByYear W21743596602019 @default.
• W2174359660 countsByYear W21743596602020 @default.
• W2174359660 countsByYear W21743596602021 @default.
• W2174359660 countsByYear W21743596602022 @default.
• W2174359660 countsByYear W21743596602023 @default.
• W2174359660 crossrefType "journal-article" @default.
• W2174359660 hasAuthorship W2174359660A5013654282 @default.
• W2174359660 hasAuthorship W2174359660A5056411116 @default.
• W2174359660 hasAuthorship W2174359660A5085709514 @default.
• W2174359660 hasAuthorship W2174359660A5091602017 @default.
• W2174359660 hasBestOaLocation W21743596602 @default.
• W2174359660 hasConcept C112392421 @default.
• W2174359660 hasConcept C126322002 @default.
• W2174359660 hasConcept C13373296 @default.
• W2174359660 hasConcept C142724271 @default.
• W2174359660 hasConcept C171958077 @default.
• W2174359660 hasConcept C198826908 @default.
• W2174359660 hasConcept C203014093 @default.
• W2174359660 hasConcept C2775838275 @default.
• W2174359660 hasConcept C2776151105 @default.
• W2174359660 hasConcept C2776914184 @default.
• W2174359660 hasConcept C2778690821 @default.

• next