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- W2174390012 abstract "Download the Issue @ a Glance podcastSubscribe to the EHJ Podcast ![Graphic][1] Atherosclerotic plaques of various types are the substrate of acute coronary syndromes (ACS), which represents the most serious complication of the disease process.1 Atherosclerosis develops over decades; in fact it already tends to start in childhood. In a thought-provoking review article, ‘Lifetime risk: childhood obesity and cardiovascular risk ’, David Celermajer from the Royal Prince Alfred Hospital in Camperdown, Australia and John Deanfield from University College London2 remind us of the potential threat of the current worldwide childhood obesity epidemic. As a result of the almost 50% increase in childhood obesity in the last 25 years, substantial concerns have been raised about the future burden of cardiovascular disease that could ensue. The authors review the evidence beyond current guideline knowledge3 linking early life obesity with adverse changes in cardiovascular structure and function already in childhood, discuss the focus on lifetime risk resulting from it, and highlight the potential effects of early lifestyle interventions.The issue continues with a Current Opinion by the ESC Working Group on Myocardial and Pericardial Diseases and members of the European Society of Human Genetics entitled ‘ The current role of next-generation DNA sequencing in routine care of patients with hereditary cardiovascular conditions ’, with Jens Mogensen from the Odense University Hospital in Denmark as the lead author. The most widely recognized indication for genetic testing in patients with cardiomyopathies,4 arrhythmic syndromes,5,6 aortopathies,7 and other cardiovascular diseases with Mendelian inheritance is to identify a causative mutation and subsequently provide pre-symptomatic or predictive testing of relatives who might be at risk of developing the disease in the future. Cascade screening of family members ensures adequate surveillance of carriers and allows … [1]: pending:yes" @default.
- W2174390012 created "2016-06-24" @default.
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- W2174390012 date "2015-06-02" @default.
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- W2174390012 title "Substrates of acute coronary syndromes: new insights into plaque rupture and erosion" @default.
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- W2174390012 doi "https://doi.org/10.1093/eurheartj/ehv149" @default.
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