FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174392433> ?p ?o ?g. }

• W2174392433 abstract "Activation of various interacting stress kinases, particularly the c-Jun N-terminal kinases (JNK), and a concomitant phosphorylation of insulin receptor substrate 1 (IRS-1) at serine 307 play a central role both in insulin resistance and in β-cell dysfunction. IRS-1 phosphorylation is stimulated by elevated free fatty acid levels through different pathways in obesity. A series of novel pyrido[2,3-d]pyrimidin-7-one derivatives were synthesized as potential antidiabetic agents, preventing IRS-1 phosphorylation at serine 307 in a cellular model of lipotoxicity and type 2 diabetes." @default.
• W2174392433 created "2016-06-24" @default.
• W2174392433 creator A5012080747 @default.
• W2174392433 creator A5021796062 @default.
• W2174392433 creator A5025613561 @default.
• W2174392433 creator A5028705634 @default.
• W2174392433 creator A5035048336 @default.
• W2174392433 creator A5039321576 @default.
• W2174392433 creator A5058578253 @default.
• W2174392433 creator A5064273602 @default.
• W2174392433 creator A5068853112 @default.
• W2174392433 creator A5068866500 @default.
• W2174392433 creator A5073849664 @default.
• W2174392433 creator A5082694472 @default.
• W2174392433 creator A5082916013 @default.
• W2174392433 creator A5085761626 @default.
• W2174392433 creator A5090328045 @default.
• W2174392433 date "2016-01-01" @default.
• W2174392433 modified "2023-10-18" @default.
• W2174392433 title "Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes" @default.
• W2174392433 cites W1765719311 @default.
• W2174392433 cites W1943260956 @default.
• W2174392433 cites W1967248026 @default.
• W2174392433 cites W1978815496 @default.
• W2174392433 cites W1999971397 @default.
• W2174392433 cites W2001442235 @default.
• W2174392433 cites W2007832743 @default.
• W2174392433 cites W2015760895 @default.
• W2174392433 cites W2017010150 @default.
• W2174392433 cites W2026550114 @default.
• W2174392433 cites W2027146027 @default.
• W2174392433 cites W2032011188 @default.
• W2174392433 cites W2040653071 @default.
• W2174392433 cites W2044070436 @default.
• W2174392433 cites W2049935015 @default.
• W2174392433 cites W2070575343 @default.
• W2174392433 cites W2079460779 @default.
• W2174392433 cites W2115795768 @default.
• W2174392433 cites W2139745857 @default.
• W2174392433 doi "https://doi.org/10.1016/j.bmcl.2015.11.099" @default.
• W2174392433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26704265" @default.
• W2174392433 hasPublicationYear "2016" @default.
• W2174392433 type Work @default.
• W2174392433 sameAs 2174392433 @default.
• W2174392433 citedByCount "10" @default.
• W2174392433 countsByYear W21743924332016 @default.
• W2174392433 countsByYear W21743924332017 @default.
• W2174392433 countsByYear W21743924332018 @default.
• W2174392433 countsByYear W21743924332019 @default.
• W2174392433 countsByYear W21743924332020 @default.
• W2174392433 countsByYear W21743924332021 @default.
• W2174392433 crossrefType "journal-article" @default.
• W2174392433 hasAuthorship W2174392433A5012080747 @default.
• W2174392433 hasAuthorship W2174392433A5021796062 @default.
• W2174392433 hasAuthorship W2174392433A5025613561 @default.
• W2174392433 hasAuthorship W2174392433A5028705634 @default.
• W2174392433 hasAuthorship W2174392433A5035048336 @default.
• W2174392433 hasAuthorship W2174392433A5039321576 @default.
• W2174392433 hasAuthorship W2174392433A5058578253 @default.
• W2174392433 hasAuthorship W2174392433A5064273602 @default.
• W2174392433 hasAuthorship W2174392433A5068853112 @default.
• W2174392433 hasAuthorship W2174392433A5068866500 @default.
• W2174392433 hasAuthorship W2174392433A5073849664 @default.
• W2174392433 hasAuthorship W2174392433A5082694472 @default.
• W2174392433 hasAuthorship W2174392433A5082916013 @default.
• W2174392433 hasAuthorship W2174392433A5085761626 @default.
• W2174392433 hasAuthorship W2174392433A5090328045 @default.
• W2174392433 hasBestOaLocation W21743924332 @default.
• W2174392433 hasConcept C112446052 @default.
• W2174392433 hasConcept C11960822 @default.
• W2174392433 hasConcept C134018914 @default.
• W2174392433 hasConcept C184235292 @default.
• W2174392433 hasConcept C185592680 @default.
• W2174392433 hasConcept C201624660 @default.
• W2174392433 hasConcept C2776414213 @default.
• W2174392433 hasConcept C2777391703 @default.
• W2174392433 hasConcept C2779306644 @default.
• W2174392433 hasConcept C2910050888 @default.
• W2174392433 hasConcept C44353895 @default.
• W2174392433 hasConcept C55493867 @default.
• W2174392433 hasConcept C86803240 @default.
• W2174392433 hasConcept C95444343 @default.
• W2174392433 hasConcept C97029542 @default.
• W2174392433 hasConceptScore W2174392433C112446052 @default.
• W2174392433 hasConceptScore W2174392433C11960822 @default.
• W2174392433 hasConceptScore W2174392433C134018914 @default.
• W2174392433 hasConceptScore W2174392433C184235292 @default.
• W2174392433 hasConceptScore W2174392433C185592680 @default.
• W2174392433 hasConceptScore W2174392433C201624660 @default.
• W2174392433 hasConceptScore W2174392433C2776414213 @default.
• W2174392433 hasConceptScore W2174392433C2777391703 @default.
• W2174392433 hasConceptScore W2174392433C2779306644 @default.
• W2174392433 hasConceptScore W2174392433C2910050888 @default.
• W2174392433 hasConceptScore W2174392433C44353895 @default.
• W2174392433 hasConceptScore W2174392433C55493867 @default.
• W2174392433 hasConceptScore W2174392433C86803240 @default.
• W2174392433 hasConceptScore W2174392433C95444343 @default.
• W2174392433 hasConceptScore W2174392433C97029542 @default.
• W2174392433 hasLocation W21743924331 @default.
• W2174392433 hasLocation W21743924332 @default.

• next