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- W2174394426 abstract "Transcranial focused ultrasound therapy is becoming a viable tool for treatment of brain related disorders. The technique has been used for treatment of essential tremors and chronic neuropathic pain with good results. In addition, the technique has a broad scope of potential applications including: tumor ablation, localized drug delivery, thrombolysis, and neurostimulation. Performing an efficient focused ultrasound treatment delivery requires planning. Accurate computational models could, in principle, be utilized to provide auxiliary guidelines for such planning. In this work, a computational model is presented for simulating the propagation of ultrasound in transcranial setting. The effects of ultrasound propagation through soft tissue and bone are modeled by coupling wave equations of fluid and solid. The coupled model is numerically evaluated by using a hybrid simulation technique that couples finite difference method with a grid method. The resulting computational model is utilized to simulate focused ultrasound field in clinical patient treatment setting. Effect of absorption of heat into the brain tissue is further simulated by using the bioheat equation. Simulation results are compared with magnetic resonance thermometry performed during the clinical treatments for evaluation of validity of the computational model." @default.
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- W2174394426 date "2015-09-01" @default.
- W2174394426 modified "2023-10-17" @default.
- W2174394426 title "Numerical simulation of transcranial focused ultrasound therapy" @default.
- W2174394426 doi "https://doi.org/10.1121/1.4933995" @default.
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