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• W2174450143 endingPage "1353" @default.
• W2174450143 startingPage "1353" @default.
• W2174450143 abstract "<ns4:p>Dengue virus (DENV) infections of humans were long thought to be self-limited and of low mortality. Beginning in the 1950s, at the time when four different DENVs were discovered, a lethal variant of dengue emerged. Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) initially observed in Southeast Asia now has spread throughout the world. Two risk factors for DHF/DSS are well-established: severe disease occurs during a second heterotypic DENV infection or during a first DENV infection in infants born to dengue-immune mothers. A large number of hypotheses have been proposed to explain severe dengue disease. As discussed, few of them attempt to explain why severe disease occurs under the two different immunological settings. New experimental evidence has demonstrated that DENV non-structural protein 1 (NS1) is toll-receptor 4 agonist that stimulates primary human myeloid cells to produce the same cytokines observed during the course of severe dengue disease. In addition, NS1 directly damages endothelial cells. These observations have been repeated and extended to an in vivo mouse model. The well-established phenomenon, antibody-dependent enhancement of DENV infection in Fc-receptor-bearing cells, should similarly enhance the production of DENV NS1 in humans, providing a unitary mechanism for severe disease in both immunological settings</ns4:p>" @default.
• W2174450143 created "2016-06-24" @default.
• W2174450143 creator A5077156970 @default.
• W2174450143 date "2015-11-25" @default.
• W2174450143 modified "2023-09-23" @default.
• W2174450143 title "Pathogenesis of Dengue: Dawn of a New Era" @default.
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• W2174450143 doi "https://doi.org/10.12688/f1000research.7024.1" @default.
• W2174450143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4754012" @default.
• W2174450143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26918141" @default.
• W2174450143 hasPublicationYear "2015" @default.
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