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- W2174548557 abstract "Background and Purpose It has been proposed that medicinal strains of cannabis and therapeutic preparations would be safer with a more balanced concentration ratio of Δ 9 ‐tetrahydrocannabinol (THC) to cannabidiol (CBD), as CBD reduces the adverse psychotropic effects of THC. However, our understanding of CBD and THC interactions is limited and the brain circuitry mediating interactions between CBD and THC are unknown. The aim of this study was to investigate whether CBD modulated the functional effects and c‐Fos expression induced by THC, using a 1:1 dose ratio that approximates therapeutic strains of cannabis and nabiximols. Experimental Approach Male C57BL/6 mice were treated with vehicle, CBD, THC or a combination of CBD and THC (10 mg·kg −1 i.p. for both cannabinoids) to examine effects on locomotor activity, anxiety‐related behaviour, body temperature and brain c‐Fos expression (a marker of neuronal activation). Key Results CBD potentiated THC‐induced locomotor suppression but reduced the hypothermic and anxiogenic effects of THC. CBD alone had no effect on these measures. THC increased brain activation as measured by c‐Fos expression in 11 of the 35 brain regions studied. CBD co‐administration suppressed THC‐induced c‐Fos expression in six of these brain regions. This effect was most pronounced in the medial preoptic nucleus and lateral periaqueductal gray. Treatment with CBD alone diminished c‐Fos expression only in the central nucleus of the amygdala compared with vehicle. Conclusions and Implications These data confirm that CBD modulated the pharmacological actions of THC and provide new information regarding brain regions involved in the interaction between CBD and THC." @default.
- W2174548557 created "2016-06-24" @default.
- W2174548557 creator A5066374356 @default.
- W2174548557 creator A5075208609 @default.
- W2174548557 date "2015-11-18" @default.
- W2174548557 modified "2023-10-11" @default.
- W2174548557 title "Neural correlates of interactions between cannabidiol and Δ<sup>9</sup>-tetrahydrocannabinol in mice: implications for medical cannabis" @default.
- W2174548557 cites W1502386496 @default.
- W2174548557 cites W1506056832 @default.
- W2174548557 cites W1514108563 @default.
- W2174548557 cites W1529023379 @default.
- W2174548557 cites W1571533074 @default.
- W2174548557 cites W1593555249 @default.
- W2174548557 cites W1801222608 @default.
- W2174548557 cites W1914573029 @default.
- W2174548557 cites W1916800927 @default.
- W2174548557 cites W1934194241 @default.
- W2174548557 cites W1945751328 @default.
- W2174548557 cites W1959296941 @default.
- W2174548557 cites W1963709167 @default.
- W2174548557 cites W1966413307 @default.
- W2174548557 cites W1970665587 @default.
- W2174548557 cites W1971729987 @default.
- W2174548557 cites W1971825415 @default.
- W2174548557 cites W1983885464 @default.
- W2174548557 cites W1985656112 @default.
- W2174548557 cites W1987685578 @default.
- W2174548557 cites W1990392127 @default.
- W2174548557 cites W1992318166 @default.
- W2174548557 cites W1994992147 @default.
- W2174548557 cites W1995591294 @default.
- W2174548557 cites W1997441120 @default.
- W2174548557 cites W2003396042 @default.
- W2174548557 cites W2003758042 @default.
- W2174548557 cites W2005235521 @default.
- W2174548557 cites W2005312899 @default.
- W2174548557 cites W2005559664 @default.
- W2174548557 cites W2006242135 @default.
- W2174548557 cites W2007918392 @default.
- W2174548557 cites W2009263798 @default.
- W2174548557 cites W2010759952 @default.
- W2174548557 cites W2013996197 @default.
- W2174548557 cites W2015830587 @default.
- W2174548557 cites W2026844512 @default.
- W2174548557 cites W2027206234 @default.
- W2174548557 cites W2039953940 @default.
- W2174548557 cites W2041273498 @default.
- W2174548557 cites W2042320851 @default.
- W2174548557 cites W2050912412 @default.
- W2174548557 cites W2053330906 @default.
- W2174548557 cites W2060978874 @default.
- W2174548557 cites W2061745435 @default.
- W2174548557 cites W2065079281 @default.
- W2174548557 cites W2075560989 @default.
- W2174548557 cites W2078696670 @default.
- W2174548557 cites W2080145415 @default.
- W2174548557 cites W2082082322 @default.
- W2174548557 cites W2087000988 @default.
- W2174548557 cites W2087381327 @default.
- W2174548557 cites W2093379263 @default.
- W2174548557 cites W2094301999 @default.
- W2174548557 cites W2099414466 @default.
- W2174548557 cites W2100987960 @default.
- W2174548557 cites W2101643484 @default.
- W2174548557 cites W2107678707 @default.
- W2174548557 cites W2114062911 @default.
- W2174548557 cites W2115115342 @default.
- W2174548557 cites W2122665945 @default.
- W2174548557 cites W2123783680 @default.
- W2174548557 cites W2123906642 @default.
- W2174548557 cites W2127612581 @default.
- W2174548557 cites W2129406235 @default.
- W2174548557 cites W2129597960 @default.
- W2174548557 cites W2132480125 @default.
- W2174548557 cites W2137234744 @default.
- W2174548557 cites W2142289946 @default.
- W2174548557 cites W2142297122 @default.
- W2174548557 cites W2144471602 @default.
- W2174548557 cites W2148841660 @default.
- W2174548557 cites W2151439032 @default.
- W2174548557 cites W2158389474 @default.
- W2174548557 cites W2160246128 @default.
- W2174548557 cites W2404147365 @default.
- W2174548557 doi "https://doi.org/10.1111/bph.13333" @default.
- W2174548557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4813392" @default.
- W2174548557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26377899" @default.
- W2174548557 hasPublicationYear "2015" @default.
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