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• W2174549751 abstract "In preclinical studies, surgery/anesthesia contribute to cognitive decline and enhance neuropathologic changes underlying Alzheimer's disease (AD). Nevertheless, the link between surgery, anesthesia, apolipoprotein E ε4 (APOE ε4), and AD remains unclear.We performed a retrospective cohort analysis of two prospective longitudinal aging studies. Mixed-effects statistical models were used to assess the relationship between surgical/anesthetic exposure, the APOE genotype, and rate of change in measures of cognition, function, and brain volumes.The surgical group (n = 182) experienced a more rapid rate of deterioration compared with the nonsurgical group (n = 345) in several cognitive, functional, and brain magnetic resonance imaging measures. Furthermore, there was a significant synergistic effect of anesthesia/surgery exposure and presence of the APOE ε4 allele in the decline of multiple cognitive and functional measures.These data provide insight into the role of surgical exposure as a risk factor for cognitive and functional decline in older adults." @default.
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• W2174549751 date "2015-11-20" @default.
• W2174549751 modified "2023-10-13" @default.
• W2174549751 title "Surgery is associated with ventricular enlargement as well as cognitive and functional decline" @default.
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• W2174549751 doi "https://doi.org/10.1016/j.jalz.2015.10.004" @default.
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