FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174549829> ?p ?o ?g. }

• W2174549829 endingPage "46" @default.
• W2174549829 startingPage "37" @default.
• W2174549829 abstract "Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the molecular mechanism of CPF toxicity to skin has not been well-characterized. The present study determined the potential mechanism involved in skin toxicity of CPF using the HaCaT human skin keratinocyte cell line. After treating to HaCaT cells, CPF triggered reactive oxygen species (ROS) generation and mitochondrial oxidative stress. We focused on NLRP3 inflammasome, known to induce innate immune response. We used mitochondrial ROS (mROS) scavenger mitoTEMPO to demonstrate a role for mROS in NLRP3 inflammasome and programmed cell death induced by CPF. Our results showed that CPF provoked NLRP3 inflammasome and pyroptosis/apoptosis via an increase of mROS in HaCaT cells. This study proposes that CPF induces innate immune response and skin inflammation through activating the NLRP3 inflammasome in skin epithelial cells. CPF may lead to cutaneous disease conditions and antioxidants could be proposed for therapy against skin exposure to CPF." @default.
• W2174549829 created "2016-06-24" @default.
• W2174549829 creator A5005745776 @default.
• W2174549829 creator A5016202074 @default.
• W2174549829 creator A5017412171 @default.
• W2174549829 creator A5017610001 @default.
• W2174549829 creator A5036424277 @default.
• W2174549829 creator A5051156041 @default.
• W2174549829 creator A5066515999 @default.
• W2174549829 creator A5082471655 @default.
• W2174549829 date "2015-12-01" @default.
• W2174549829 modified "2023-10-10" @default.
• W2174549829 title "Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells" @default.
• W2174549829 cites W1506642042 @default.
• W2174549829 cites W1543729365 @default.
• W2174549829 cites W1571910978 @default.
• W2174549829 cites W1605844554 @default.
• W2174549829 cites W1891826181 @default.
• W2174549829 cites W1963492948 @default.
• W2174549829 cites W1976391651 @default.
• W2174549829 cites W1981120301 @default.
• W2174549829 cites W1985538633 @default.
• W2174549829 cites W1992815676 @default.
• W2174549829 cites W1994377742 @default.
• W2174549829 cites W1997816382 @default.
• W2174549829 cites W1999349182 @default.
• W2174549829 cites W2002225831 @default.
• W2174549829 cites W2004391012 @default.
• W2174549829 cites W2006120701 @default.
• W2174549829 cites W2009395778 @default.
• W2174549829 cites W2021358525 @default.
• W2174549829 cites W2021693564 @default.
• W2174549829 cites W2023954822 @default.
• W2174549829 cites W2028823314 @default.
• W2174549829 cites W2033448006 @default.
• W2174549829 cites W2035672592 @default.
• W2174549829 cites W2036803537 @default.
• W2174549829 cites W2041967565 @default.
• W2174549829 cites W2046380842 @default.
• W2174549829 cites W2062671133 @default.
• W2174549829 cites W2066003843 @default.
• W2174549829 cites W2071684520 @default.
• W2174549829 cites W2074952191 @default.
• W2174549829 cites W2080913553 @default.
• W2174549829 cites W2084998907 @default.
• W2174549829 cites W2087790613 @default.
• W2174549829 cites W2089154184 @default.
• W2174549829 cites W2089503694 @default.
• W2174549829 cites W2094156327 @default.
• W2174549829 cites W2096545094 @default.
• W2174549829 cites W2104874461 @default.
• W2174549829 cites W2109771497 @default.
• W2174549829 cites W2116697737 @default.
• W2174549829 cites W2117231363 @default.
• W2174549829 cites W2121369239 @default.
• W2174549829 cites W2131811820 @default.
• W2174549829 cites W2138302361 @default.
• W2174549829 cites W2148125367 @default.
• W2174549829 cites W2170936782 @default.
• W2174549829 doi "https://doi.org/10.1016/j.tox.2015.09.006" @default.
• W2174549829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26435000" @default.
• W2174549829 hasPublicationYear "2015" @default.
• W2174549829 type Work @default.
• W2174549829 sameAs 2174549829 @default.
• W2174549829 citedByCount "68" @default.
• W2174549829 countsByYear W21745498292016 @default.
• W2174549829 countsByYear W21745498292017 @default.
• W2174549829 countsByYear W21745498292018 @default.
• W2174549829 countsByYear W21745498292019 @default.
• W2174549829 countsByYear W21745498292020 @default.
• W2174549829 countsByYear W21745498292021 @default.
• W2174549829 countsByYear W21745498292022 @default.
• W2174549829 countsByYear W21745498292023 @default.
• W2174549829 crossrefType "journal-article" @default.
• W2174549829 hasAuthorship W2174549829A5005745776 @default.
• W2174549829 hasAuthorship W2174549829A5016202074 @default.
• W2174549829 hasAuthorship W2174549829A5017412171 @default.
• W2174549829 hasAuthorship W2174549829A5017610001 @default.
• W2174549829 hasAuthorship W2174549829A5036424277 @default.
• W2174549829 hasAuthorship W2174549829A5051156041 @default.
• W2174549829 hasAuthorship W2174549829A5066515999 @default.
• W2174549829 hasAuthorship W2174549829A5082471655 @default.
• W2174549829 hasConcept C118995209 @default.
• W2174549829 hasConcept C17172800 @default.
• W2174549829 hasConcept C185592680 @default.
• W2174549829 hasConcept C190283241 @default.
• W2174549829 hasConcept C202751555 @default.
• W2174549829 hasConcept C203014093 @default.
• W2174549829 hasConcept C2776151105 @default.
• W2174549829 hasConcept C2776914184 @default.
• W2174549829 hasConcept C2777074287 @default.
• W2174549829 hasConcept C2777209026 @default.
• W2174549829 hasConcept C31573885 @default.
• W2174549829 hasConcept C48349386 @default.
• W2174549829 hasConcept C55493867 @default.
• W2174549829 hasConcept C86803240 @default.
• W2174549829 hasConcept C95444343 @default.
• W2174549829 hasConcept C98274493 @default.

• next