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- W2174598103 abstract "The advent of induced pluripotent stem cells (iPSC) has transformed the classic approach of studying human disease, providing in vitro access to disease-relevant cells from patients for the study of disease pathogenesis and for drug screening. However, in spite of the broad repertoire of iPSC-based disease models developed in recent years, increasing evidence suggests that this technology might not be fully suitable for the study of conditions of old age, such as neurodegeneration. The difficulty in recapitulating late-stage features of disease in cells of pluripotent origin is believed to be a discrepancy between the fetal-like nature of iPSC-progeny and the advanced age of onset of neurodegenerative syndromes. In parallel to the issue of functional immaturity known to affect derivatives of pluripotent cells, latest findings suggest that reprogramming also subjects cells to a process of rejuvenation, giving rise to cells that are too young to manifest phenotypes of age-related diseases. Thus, following the significant progress in manipulating cellular fate, the stem cell field will now have to face the new challenge of controlling cellular age, in order to fully harness the potential of iPSC-technology to advance the research and cure of diseases of the aging brain. This article is part of a Special Issue entitled SI: Exploiting human neurons." @default.
- W2174598103 created "2016-06-24" @default.
- W2174598103 creator A5062179210 @default.
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- W2174598103 date "2017-02-01" @default.
- W2174598103 modified "2023-09-26" @default.
- W2174598103 title "Back and forth in time: Directing age in iPSC-derived lineages" @default.
- W2174598103 cites W1483496013 @default.
- W2174598103 cites W1599031322 @default.
- W2174598103 cites W1963646113 @default.
- W2174598103 cites W1964551999 @default.
- W2174598103 cites W1965529656 @default.
- W2174598103 cites W1969720106 @default.
- W2174598103 cites W1969905245 @default.
- W2174598103 cites W1972975669 @default.
- W2174598103 cites W1974047233 @default.
- W2174598103 cites W1977049211 @default.
- W2174598103 cites W1977789101 @default.
- W2174598103 cites W1978927200 @default.
- W2174598103 cites W1980825524 @default.
- W2174598103 cites W1985010554 @default.
- W2174598103 cites W1987167495 @default.
- W2174598103 cites W1990381590 @default.
- W2174598103 cites W1990916340 @default.
- W2174598103 cites W1994504773 @default.
- W2174598103 cites W1996059719 @default.
- W2174598103 cites W1996603253 @default.
- W2174598103 cites W1997773274 @default.
- W2174598103 cites W1999893655 @default.
- W2174598103 cites W2000151960 @default.
- W2174598103 cites W2003126320 @default.
- W2174598103 cites W2003835684 @default.
- W2174598103 cites W2005097929 @default.
- W2174598103 cites W2008370035 @default.
- W2174598103 cites W2009705816 @default.
- W2174598103 cites W2011024729 @default.
- W2174598103 cites W2011169427 @default.
- W2174598103 cites W2018286352 @default.
- W2174598103 cites W2020156629 @default.
- W2174598103 cites W2022156309 @default.
- W2174598103 cites W2022487205 @default.
- W2174598103 cites W2023652080 @default.
- W2174598103 cites W2025738240 @default.
- W2174598103 cites W2027165392 @default.
- W2174598103 cites W2031611126 @default.
- W2174598103 cites W2032472678 @default.
- W2174598103 cites W2033799616 @default.
- W2174598103 cites W2034879573 @default.
- W2174598103 cites W2037146644 @default.
- W2174598103 cites W2040027262 @default.
- W2174598103 cites W2041848964 @default.
- W2174598103 cites W2043003592 @default.
- W2174598103 cites W2050865611 @default.
- W2174598103 cites W2051785391 @default.
- W2174598103 cites W2054186703 @default.
- W2174598103 cites W2055002688 @default.
- W2174598103 cites W2057084831 @default.
- W2174598103 cites W2057431271 @default.
- W2174598103 cites W2058484936 @default.
- W2174598103 cites W2061101624 @default.
- W2174598103 cites W2062093164 @default.
- W2174598103 cites W2063156659 @default.
- W2174598103 cites W2063996210 @default.
- W2174598103 cites W2066442023 @default.
- W2174598103 cites W2066843562 @default.
- W2174598103 cites W2067432938 @default.
- W2174598103 cites W2069498125 @default.
- W2174598103 cites W2073244138 @default.
- W2174598103 cites W2073252618 @default.
- W2174598103 cites W2073947789 @default.
- W2174598103 cites W2074314696 @default.
- W2174598103 cites W2075697181 @default.
- W2174598103 cites W2076289829 @default.
- W2174598103 cites W2077007919 @default.
- W2174598103 cites W2077748688 @default.
- W2174598103 cites W2079870118 @default.
- W2174598103 cites W2081914422 @default.
- W2174598103 cites W2082682623 @default.
- W2174598103 cites W2087786585 @default.
- W2174598103 cites W2088714934 @default.
- W2174598103 cites W2088778610 @default.
- W2174598103 cites W2092834304 @default.
- W2174598103 cites W2093643639 @default.
- W2174598103 cites W2095455882 @default.
- W2174598103 cites W2098009444 @default.
- W2174598103 cites W2100959085 @default.
- W2174598103 cites W2101185010 @default.
- W2174598103 cites W2101631778 @default.
- W2174598103 cites W2102424187 @default.
- W2174598103 cites W2103540918 @default.
- W2174598103 cites W2103667407 @default.
- W2174598103 cites W2108700752 @default.
- W2174598103 cites W2109427914 @default.
- W2174598103 cites W2111888351 @default.
- W2174598103 cites W2114206069 @default.
- W2174598103 cites W2114840727 @default.
- W2174598103 cites W2114872355 @default.
- W2174598103 cites W2116695601 @default.