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• W2174598926 abstract "In order to find novel nonhydroxamate histone deacetylase (HDAC) inhibitors, a series of thiol-based compounds modeled after suberoylanilide hydroxamic acid (SAHA) was synthesized, and their inhibitory effect on HDACs was evaluated. Compound 6, in which the hydroxamic acid of SAHA was replaced by a thiol, was found to be as potent as SAHA, and optimization of this series led to the identification of HDAC inhibitors more potent than SAHA." @default.
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• W2174598926 date "2004-06-01" @default.
• W2174598926 modified "2023-10-10" @default.
• W2174598926 title "Thiol-based SAHA analogues as potent histone deacetylase inhibitors" @default.
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• W2174598926 doi "https://doi.org/10.1016/j.bmcl.2004.03.063" @default.
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