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• W2174619471 abstract "Novel potent derivatives of N-(aryl)-4-(azolylethyl)thiazole-5-carboxamides are described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Several compounds display VEGFR-2 inhibitory activity reaching IC(50)<100 nM in both enzymatic and cellular assays. The compounds also inhibit the related tyrosine kinase, VEGFR-1. By controlling the substitution pattern on the 5-carboxamido pharmacophore, both dual and specific VEGFR-2 thiazoles were identified." @default.
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• W2174619471 date "2006-02-01" @default.
• W2174619471 modified "2023-10-18" @default.
• W2174619471 title "N-(Aryl)-4-(azolylethyl)thiazole-5-carboxamides: Novel potent inhibitors of VEGF receptors I and II" @default.
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• W2174619471 doi "https://doi.org/10.1016/j.bmcl.2005.10.058" @default.
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