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• W2174642786 abstract "The innate immune system is an ancient surveillance system able to sense microbial invaders as well as aberrations in normal cell function. No longer viewed as a static and non-specific part of immunity, the innate immune system employs a plethora of specialized pattern recognition sensors to monitor and achieve homeostasis; these include the Toll-like receptors, the retinoic acid-inducible gene-like receptors, the nucleotide-binding oligomerization domain receptors (NLRs), the C-type lectins and the complement system. In order to increase specificity and diversity, innate immunity uses homotypic and heterotypic associations among these different components. Multi-molecular assemblies are formed both on the cell surface and in the cytosol to respond to pathogen and danger signals. Diverse, but tailored, responses to a changing environment are orchestrated depending on the the nature of the challenge and the repertoire of interacting receptors and components available in the sensing cell. It is now emerging that innate immunity operates a system of ‘checks and balances’ where interaction among the sensors is key in maintaining normal cell function. Complement sits at the heart of this alarm system and it is becoming apparent that it is capable of interacting with all the other pathways to effect a tailored immune response. In this review, we will focus on complement interactions with NLRs, the so-called ‘inflammasomes’, describing the molecular mechanisms that have been revealed so far and discussing the circumstantial evidence that exists for these interactions in disease states." @default.
• W2174642786 created "2016-06-24" @default.
• W2174642786 creator A5007839648 @default.
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• W2174642786 creator A5090087019 @default.
• W2174642786 creator A5090102833 @default.
• W2174642786 date "2016-01-19" @default.
• W2174642786 modified "2023-10-12" @default.
• W2174642786 title "Complementing the inflammasome" @default.
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